Evidence map›Paper›PMID 41780731›Full record

Trial reportThe American journal of clinical nutrition2026

Independent effects of whey protein and alkali supplementation on muscle health in healthy older adults: factorial randomized controlled trial.

Lisa Ceglia, Elsa Konieczynski, Elise Danico, Ludovic Trinquart, Benjamin Koethe, Qingyan Xiang, Roger A Fielding, William J Evans, Mahalakshmi Shankaran, Bess Dawson-Hughes

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of clinical nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04048616 (Impact of Protein and Alkali Supplementation on Skeletal Muscle in Older Adults), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04048616 nacompletednot on this map

Impact of Protein and Alkali Supplementation on Skeletal Muscle in Older Adults

TypeinterventionalSponsorTufts UniversityRan2021 to 2023Enrolled141ConditionsAge-Related Sarcopenia, Muscle LossArmswhey protein isolate, potassium bicarbonate (KHCO3), microcrystalline cellulose, maltodextrin powder
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lisa CegliaDivision of Endocrinology, Diabetes and Metabolism, Tufts Medical Center, Boston, MA, United States; Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, United States. Electronic address: lisa.ceglia@tufts.edu.
Elsa KonieczynskiJean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, United States.
Elise DanicoJean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, United States.
Ludovic TrinquartTufts Clinical and Translational Science Institute, Tufts University, Boston, MA, United States; Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, United States.
Benjamin KoetheTufts Clinical and Translational Science Institute, Tufts University, Boston, MA, United States; Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, United States.
Qingyan XiangTufts Clinical and Translational Science Institute, Tufts University, Boston, MA, United States; Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, United States.
Roger A FieldingJean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, United States.
William J EvansDepartment of Nutritional Sciences & Toxicology, University of California, Berkeley, CA, United States.
Mahalakshmi ShankaranDepartment of Nutritional Sciences & Toxicology, University of California, Berkeley, CA, United States.
Bess Dawson-HughesJean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, United States.

Funding

Impact of protein and alkali supplementation on skeletal muscle in older adultsR01AG055443 · NIA · TUFTS UNIVERSITY BOSTON · PI CEGLIA, LISA · 2018 to 2024
$2.0M
NIA NIH HHS R01 AG055443
6 · The paper itself

Abstract

backgroundAging is accompanied by reduced muscle protein synthesis and increased circulating acid, both of which contribute to declines in muscle health.

objectivesTo determine the effects of whey protein (WP) and alkali (potassium bicarbonate, KHCO

methodsIn this randomized, 2 × 2 factorial, placebo-controlled study, healthy adults aged ≥65 years were assigned to either WP (1.5 g/kg/d) plus KHCO

resultsIn the intention-to-treat sample (n = 128), 47.7% were female, mean ± SD age was 74 ± 6 y, and baseline protein intake was 0.85 ± 0.30 g/kg/d. Neither WP nor KHCO

conclusionsIn healthy free-living older adults reporting a protein intake at the current recommended daily allowance, neither increasing protein to 1.5 g/kg/d with WP nor adding a KHCO CLINICAL TRIAL REGISTRY NUMBER: This trial was registered as NCT04048616 at https://clinicaltrials.gov/study/NCT04048616?term=ceglia&rank=1.

Indexed as

BicarbonatesDietary SupplementsMuscle, SkeletalPotassium CompoundsWhey ProteinsAgedAged, 80 and overDouble-Blind MethodFemaleHumansInsulin-Like Growth Factor IMaleMuscle StrengthBicarbonatesInsulin-Like Growth Factor Ipotassium bicarbonatePotassium CompoundsWhey Proteinsalkalilean massmuscle massmuscle strengtholder adultspotassium bicarbonateskeletal musclewhey protein

Identifiers

PMID41780731
PMCPMC13104605

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.