Evidence map›Paper›PMID 41780671›Full record

ArticleThe Journal of pediatrics2026

Associations between Prenatal Perceived Stress and Child Autism-Related Traits in the ECHO Cohort.

Luke P Grosvenor, Monica McGrath, Jasmine Douglas, Jennifer L Ames, Ndidiamaka Amutah-Onukagha, Lyndsay A Avalos, Brennan H Baker, Patricia A Brennan, Neika Christalin, Assiamira Ferrara and 6 more

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Article in The Journal of pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Luke P GrosvenorDivision of Research, Kaiser Permanente Northern California, Pleasanton, CA. Electronic address: luke.p.grosvenor@kp.org.
Monica McGrathDepartment of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD.
Jasmine DouglasDepartment of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD.
Jennifer L AmesDivision of Research, Kaiser Permanente Northern California, Pleasanton, CA.
Ndidiamaka Amutah-OnukaghaDepartment of Public Health and Community Medicine, Tufts University School of Medicine, Boston, MA.
Lyndsay A AvalosDivision of Research, Kaiser Permanente Northern California, Pleasanton, CA; Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, CA.
Brennan H BakerDepartment of Environmental & Occupational Health Sciences, University of Washington School of Public Health, Seattle, WA; Center for Child Health, Behavior and Development, Seattle Children's Research Institute, Seattle, WA.
Patricia A BrennanDepartment of Psychology, Emory University, Atlanta, GA.
Neika ChristalinDepartment of Public Health and Community Medicine, Tufts University School of Medicine, Boston, MA.
Assiamira FerraraDivision of Research, Kaiser Permanente Northern California, Pleasanton, CA.
Kendria Kelly-TaylorDivision of Research, Kaiser Permanente Northern California, Pleasanton, CA.
Kristen LyallDepartment of Epidemiology and Biostatistics, Dornsife School of Public Health, Philadelphia, PA; A.J. Drexel Autism Institute, Drexel University, Philadelphia, PA.
Ruby H N NguyenDivision of Epidemiology & Community Health, University of Minnesota School of Public Health, Minneapolis, MN.
Rebecca J SchmidtDepartment of Public Health Sciences, University of California, Davis, Davis, CA; The MIND Institute, University of California Davis, Sacramento, CA.
Lisa A CroenDivision of Research, Kaiser Permanente Northern California, Pleasanton, CA; Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, CA.
ECHO Cohort Consortium

Funding

Project-005U2COD023375 · OD · DUKE UNIVERSITY · PI Linda S Adair, Phillip Brian Smith · 2016 to 2026
$215.9M
ECHODAC (Environmental Influences on Child Health Outcomes Data Analysis Center)U24OD023382 · OD · JOHNS HOPKINS UNIVERSITY · PI Diane J Catellier, LISA P JACOBSON · 2016 to 2026
$148.4M
The ECHO Measurement Core: A Framework and Resource for Assessing Environmental Exposure and Child HealthU24OD023319 · OD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Courtney K Blackwell, RICHARD GERSHON · 2016 to 2026
$43.7M
Prenatal and Early Childhood Pathways To Health:  An Integrated Model of Chemical and Social Exposures, Biological Mechanisms, and Sex-Specific Effects on Neurodevelopment and Respiratory OutcomesUH3OD023271 · OD · UNIVERSITY OF WASHINGTON · PI BUSH, NICOLE RENEE, KARR, CATHERINE J · 2018 to 2022
$37.3M
ECHO Laboratory Core at Vanderbilt for Integrated Sample Biobanking and ProcessingU24OD035523 · OD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Suman Ranjan Das, NATASHA Bassam HALASA · 2023 to 2026
$32.8M
Lifecourse Approach to Developmental Repercussions of Environmental Agents on Metabolic and Respiratory Health (LA DREAMERs)UH3OD023287 · OD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BASTAIN, THERESA M, BRETON, CARRIE VAN DOREN · 2018 to 2022
$28.4M
Statistical Services and Methods Development ResourceU2CES026555 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GENNINGS, CHRIS · 2015 to 2025
$26.4M
Early Life Exposure to Endocrine Disrupting Chemicals and Child Growth, Adiposity, and NeurodevelopmentUH3OD023289 · OD · KAISER FOUNDATION RESEARCH INSTITUTE · PI ASSIAMIRA FERRARA, Monique Marie Hedderson · 2018 to 2026
$25.1M
Untargeted Analysis ResourceU2CES026561 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI WRIGHT, ROBERT O · 2015 to 2025
$24.5M
Early Life Stress and the Environmental Origins of Disease: a Population-based Prospective Longitudinal Study of Children in Rural Poverty (ECHO)UH3OD023332 · OD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI KOPP, LISA MICHELLE, SWINGLER, MARGARET M. · 2018 to 2022
$22.7M
ENVIRONMENTAL INFLUENCES ON NEURODEVELOPMENTAL OUTCOME IN INFANTS BORN VERY PRETERMUH3OD023347 · OD · WOMEN AND INFANTS HOSPITAL-RHODE ISLAND · PI LESTER, BARRY M., MARSIT, CARMEN JOSEPH · 2018 to 2022
$18.4M
BREAKING THE CYCLE OF INTERGENERATIONAL DISADVANTAGE: NEURODEVELOPMENT AMONG PUERTO RICAN CHILDREN.UH3OD023328 · OD · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI CANINO, GLORISA J, DUARTE, CRISTIANE S. · 2018 to 2022
$18.3M
NIEHS NIH HHS U24 ES026539NIEHS NIH HHS U2C ES026533NIEHS NIH HHS U2C ES026542NIEHS NIH HHS U2C ES026555NIEHS NIH HHS U2C ES026561NIEHS NIH HHS U2C ES030851NIEHS NIH HHS U2C ES030857NIEHS NIH HHS U2C ES030859NIH HHS U24 OD023319NIH HHS U24 OD023382NIH HHS U24 OD035523NIH HHS U2C OD023375NIH HHS UG3 OD023289NIH HHS UG3 OD035508NIH HHS UG3 OD035509NIH HHS UG3 OD035513NIH HHS UG3 OD035516NIH HHS UG3 OD035517NIH HHS UG3 OD035518NIH HHS UG3 OD035519NIH HHS UG3 OD035521NIH HHS UG3 OD035526NIH HHS UG3 OD035527NIH HHS UG3 OD035528NIH HHS UG3 OD035529NIH HHS UG3 OD035532NIH HHS UG3 OD035533NIH HHS UG3 OD035536NIH HHS UG3 OD035537NIH HHS UG3 OD035540NIH HHS UG3 OD035542NIH HHS UG3 OD035543NIH HHS UG3 OD035544NIH HHS UG3 OD035546NIH HHS UG3 OD035550NIH HHS UH3 OD023268NIH HHS UH3 OD023271NIH HHS UH3 OD023286NIH HHS UH3 OD023287NIH HHS UH3 OD023289NIH HHS UH3 OD023318NIH HHS UH3 OD023320NIH HHS UH3 OD023328NIH HHS UH3 OD023332NIH HHS UH3 OD023347NIH HHS UH3 OD035540
6 · The paper itself

Abstract

objectiveTo examine associations of prenatal perceived stress with child autism-related traits and to evaluate effect modification by both child sex and co-occurring prenatal depressive symptoms. STUDY

designThe sample was drawn from Environmental Influences on Child Health Outcomes cohort sites with data on prenatal perceived stress (Perceived Stress Scale [PSS]) and autism-related traits (Social Responsiveness Scale, second Edition [SRS-2]). We used linear and logistic regression models to determine associations between PSS and either SRS-2 T-scores or odds of moderate-to-severe autism-related traits (SRS-2 T-score ≥65) and evaluated effect modification by sex and prenatal depressive symptoms.

resultsAmong 4115 mother-child pairs, higher PSS was associated with increased severity of autism-related traits (β = 0.15 [95% CI = 0.13-0.18]) and odds of moderate-to-severe traits (OR = 1.04 [1.04-1.05]). There was evidence for sex-by-exposure interaction for continuous (β

conclusionsWe found small yet significant associations between prenatal stress and autism-related traits. Limited evidence for effect modification by sex or prenatal depressive symptoms suggests prenatal perceived stress influences autism-related traits after accounting for these factors.

Indexed as

Autistic DisorderPregnancy ComplicationsPrenatal Exposure Delayed EffectsStress, PsychologicalAdultChildChild, PreschoolCohort StudiesDepressionFemaleHumansMalePregnancySubjective Stressautism spectrum disorderneurodevelopmentprenatal stresspsychosocial health

Identifiers

PMID41780671
PMCPMC13089960

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.