Evidence map›Paper›PMID 41780670›Full record

ArticleThe Journal of pediatrics2026

Central Precocious Puberty and Optic Pathway Glioma in Children with Neurofibromatosis 1: Associations with Tumor Location, Vision, and Treatment.

Julia Katz, Ethan Hillis, Jenny P Garzon, Robert Listernick, Carlos E Prada, Aditi Gupta, David H Gutmann

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Julia KatzDepartment of Pediatrics, St. Louis Children's Hospital and Washington University, St. Louis, MO.
Ethan HillisDepartment of Medicine and Institute for Informatics, Data Science, and Biostatistics, Washington University, St. Louis, MO.
Jenny P GarzonEdwards Family Division of Genetics and Rare Diseases, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL; Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL.
Robert ListernickDepartment of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL.
Carlos E PradaEdwards Family Division of Genetics and Rare Diseases, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL; Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL.
Aditi GuptaDepartment of Medicine and Institute for Informatics, Data Science, and Biostatistics, Washington University, St. Louis, MO.
David H GutmannDepartment of Neurology, Washington University, St. Louis, MO. Electronic address: gutmannd@wustl.edu.

Funding

Personalized risk assessment in Neurofibromatosis Type 1R01NS131112 · NINDS · WASHINGTON UNIVERSITY · PI Aditi Gupta, PHILIP R.O. PAYNE · 2023 to 2026
$2.2M
NINDS NIH HHS R01 NS131112
6 · The paper itself

Abstract

Neurofibromatosis 1-associated optic pathway gliomas (OPGs) may co-occur with central precocious puberty (CPP). Using large language model-based data analysis from 2 NF centers, we compared OPGs in children with NF1, with and without CPP. CPP was associated with hypothalamic involvement, poorer vision, and a higher likelihood of OPG treatment.

Indexed as

Neurofibromatosis 1Optic Nerve GliomaPuberty, PrecociousChildChild, PreschoolFemaleHumansMaleRetrospective StudiesVisual Acuityastrocytomalarge language modelneurofibromatosisNF1visual acuity

Identifiers

PMID41780670
PMCPMC13288148

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.