ArticleThe Journal of allergy and clinical immunology2026
Group 2 innate lymphoid cells program pulmonary adaptive immunity via granulocyte-macrophage colony-stimulating factor.
Article in The Journal of allergy and clinical immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The trial behind it
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Who cites it
2 citing papers in PubMed.
- Homeostatic Regulation of Lung Dendritic Cells at Steady State.Immune network · 2026Review
- Innate airway immune response to fungal allergens.Frontiers in immunology · 2026Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundGroup 2 innate lymphoid cells (ILC2s) and CD4
objectiveWe investigated the roles of ILC2s in establishing adaptive antigen-specific immunity in a mouse model of human asthma.
methodsILC2-deficient mice were intranasally sensitized to ovalbumin (OVA) using Alternaria extract as an adjuvant. Innate and adaptive responses were assessed by flow cytometry and by intranasal OVA recall challenge. The underlying mechanisms were investigated using gene-deficient mice, in vivo antibody neutralization, adoptive transfer of ILC2s, and in vitro culture systems.
resultsExposure of naive mice to the fungal allergen Alternaria increased the number of lung dendritic cells (DCs), activated migratory DCs, and promoted DC production of the T
conclusionILC2s license lung DCs via granulocyte-macrophage colony-stimulating factor to prime and recruit T
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