Non-nutritive sweeteners attenuate reinforced cephalic phase insulin release and impair glucose tolerance in mice.

Tomonari Otsuki, Keiji Okihara, Kengo Nomura, Sho Matsui, Akiyuki Taruno, Tsutomu Sasaki

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Article in The journal of physiological sciences : JPS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

Tomonari OtsukiLaboratory of Nutrition Chemistry, Division of Food and Biomolecular Sciences, Graduate School of Agriculture, Kyoto University, Kyoto, Kyoto 606-8502, Japan.

Keiji OkiharaLaboratory of Nutrition Chemistry, Division of Food and Biomolecular Sciences, Graduate School of Agriculture, Kyoto University, Kyoto, Kyoto 606-8502, Japan.

Kengo NomuraDepartment of Molecular Cell Physiology, Kyoto Prefectural University of Medicine, Kyoto, Kyoto 602-8566, Japan; Department of Cellular and Molecular Physiology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.

Sho MatsuiLaboratory of Nutrition Chemistry, Division of Food and Biomolecular Sciences, Graduate School of Agriculture, Kyoto University, Kyoto, Kyoto 606-8502, Japan.

Akiyuki TarunoDepartment of Molecular Cell Physiology, Kyoto Prefectural University of Medicine, Kyoto, Kyoto 602-8566, Japan; Department of Cellular and Molecular Physiology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.

Tsutomu SasakiLaboratory of Nutrition Chemistry, Division of Food and Biomolecular Sciences, Graduate School of Agriculture, Kyoto University, Kyoto, Kyoto 606-8502, Japan. Electronic address: sasaki.tsutomu.5m@kyoto-u.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-nutritive artificial sweeteners (NNSs) which provide sweetness with minimal calories are used to reduce sugar consumption, while orosensory stimuli such as sweet taste can stimulate insulin secretion known as cephalic phase insulin release (CPIR). Whether the use of NNSs affects CPIR and glucose homeostasis remains unclear. Here, we report that NNSs impair CPIR reinforced by glucose solution conditioning and disturb glucose homeostasis in mice without affecting peripheral sensing of the tastant through the chorda tympani nerve. We established a protocol for reinforcing CPIR and detecting it in male C57BL/6 mice. Consumption of the NNSs for 2 days impaired the reinforced CPIR and the improved glucose tolerance by the consumption of 1 M glucose solution. These results suggest that NNS impairs glucose tolerance partly by disturbing CPIR in mice.

Indexed as

Glucose IntoleranceInsulinInsulin SecretionNon-Nutritive SweetenersSweetening AgentsAnimalsBlood GlucoseChorda Tympani NerveGlucoseGlucose Tolerance TestMaleMiceMice, Inbred C57BLTasteBlood GlucoseGlucoseInsulinNon-Nutritive SweetenersSweetening AgentsCephalic phase insulin releaseChorda tympani nerveGlucose toleranceNon-nutritive sweeteners

Identifiers

PMID41780154

DOI10.1016/j.jphyss.2026.100066

PMCPMC12969289

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.