Evidence map›Paper›PMID 41779895›Full record

ArticleACS applied materials & interfaces2026

Alkyne Nitro Tag Enables Stable and Efficient Protein Functionalization of Gold Nanoparticles.

Shun-Qiang Xu, Yung-Kun Pan, Po-Cheng Lin, Ling-Ling Weng, Tzu-Jung Chang, Chien-Chi Wu, Yun-Rong Peng, Kui-Thong Tan

Abstract read
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In one paragraph

Article in ACS applied materials & interfaces, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shun-Qiang XuDepartment of Chemistry, National Tsing Hua University, 101 Section 2, Kuang Fu Road, Hsinchu 30013, Taiwan, Republic of China.
Yung-Kun PanDepartment of Chemistry, National Tsing Hua University, 101 Section 2, Kuang Fu Road, Hsinchu 30013, Taiwan, Republic of China.
Po-Cheng LinDepartment of Chemistry, National Tsing Hua University, 101 Section 2, Kuang Fu Road, Hsinchu 30013, Taiwan, Republic of China.
Ling-Ling WengDepartment of Chemistry, National Tsing Hua University, 101 Section 2, Kuang Fu Road, Hsinchu 30013, Taiwan, Republic of China.
Tzu-Jung ChangDepartment of Chemistry, National Tsing Hua University, 101 Section 2, Kuang Fu Road, Hsinchu 30013, Taiwan, Republic of China.
Chien-Chi WuDepartment of Chemistry, National Tsing Hua University, 101 Section 2, Kuang Fu Road, Hsinchu 30013, Taiwan, Republic of China.
Yun-Rong PengDepartment of Chemistry, National Tsing Hua University, 101 Section 2, Kuang Fu Road, Hsinchu 30013, Taiwan, Republic of China.
Kui-Thong TanDepartment of Chemistry, National Tsing Hua University, 101 Section 2, Kuang Fu Road, Hsinchu 30013, Taiwan, Republic of China.ORCID 0000-0002-0091-8546

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Surface ligands play a critical role in the preparation of stable, covalently bound nanoparticle-protein conjugates. However, large surface ligands often introduce steric and antifouling effects that reduce protein conjugation yields, whereas small ligands tend to induce nanoparticle aggregation during activation. Here, we report Alkyne Nitro Tag (

Indexed as

AlkynesGoldImmunoglobulin GMetal NanoparticlesStreptavidinHorseradish PeroxidaseSurface PropertiesAlkynesGoldHorseradish PeroxidaseImmunoglobulin GStreptavidinalkynegold nanoparticlesnitrobenzeneprotein functionalizationsurface modification

Identifiers

PMID41779895
PMCPMC13006950

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.