Evidence map›Paper›PMID 41779877›Full record

ArticleJournal of the American Chemical Society2026

A Single Flavoenzyme Forges the Pentacyclic Skeleton of α-Cyclopiazonic Acid.

Minjun Wang, Ting Cheng, Wenyuan Zhang, You-Ming Kuo, Yuexuan Li, Yue Yan, Po-Yun Hisao, Chin-Yuan Chang, Nan Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Minjun WangState Key Laboratory of Ocean Sensing & Ocean College, Zhejiang University, Zhoushan 316021, China.
Ting ChengDepartment of Biological Science and Technology, Center for Intelligent Drug Systems and Smart Biodevices (IDS2B), National Yang Ming Chiao Tung University, Hsinchu 30010, Taiwan, ROC.
Wenyuan ZhangState Key Laboratory of Ocean Sensing & Ocean College, Zhejiang University, Zhoushan 316021, China.
You-Ming KuoDepartment of Biological Science and Technology, Center for Intelligent Drug Systems and Smart Biodevices (IDS2B), National Yang Ming Chiao Tung University, Hsinchu 30010, Taiwan, ROC.
Yuexuan LiState Key Laboratory of Ocean Sensing & Ocean College, Zhejiang University, Zhoushan 316021, China.
Yue YanState Key Laboratory of Ocean Sensing & Ocean College, Zhejiang University, Zhoushan 316021, China.
Po-Yun HisaoDepartment of Biological Science and Technology, Center for Intelligent Drug Systems and Smart Biodevices (IDS2B), National Yang Ming Chiao Tung University, Hsinchu 30010, Taiwan, ROC.
Chin-Yuan ChangDepartment of Biological Science and Technology, Center for Intelligent Drug Systems and Smart Biodevices (IDS2B), National Yang Ming Chiao Tung University, Hsinchu 30010, Taiwan, ROC.
Nan WangState Key Laboratory of Ocean Sensing & Ocean College, Zhejiang University, Zhoushan 316021, China.ORCID 0000-0001-7171-0913

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The biosynthesis of α-cyclopiazonic acid (α-CPA) is notable for generating a complex pentacyclic scaffold using a minimal three-enzyme pathway. The final step, catalyzed by CpaO, converts linear β-CPA into α-CPA through an enigmatic oxidative cyclization. Here, we report the structural and mechanistic characterization of CpaO. X-ray crystallography reveals a three-domain architecture belonging to the flavin-dependent amine oxidase (FAO) superfamily, while CpaO represents a previously undescribed subfamily distinguished by an essential, covalently linked FAD (8α-

Indexed as

IndolesCatalytic DomainCrystallography, X-RayModels, MolecularStereoisomerismIndoles

Identifiers

PMID41779877
PMCPMC13003489

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.