Evidence map›Paper›PMID 41779872›Full record

ArticleScience translational medicine2026

Modulating alternative splicing of

Harini P Tirumala, Li Wang, Yan Li, Sameer S Bajikar, Ashley G Anderson, Wei Wang, Alexander J Trostle, Mahla Zahabiyon, Aleksandar Bajic, Jean J Kim and 3 more

Abstract read
In one paragraph

Article in Science translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Exon skipping to treat Rett syndrome.Nature reviews. Drug discovery · 2026
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Harini P TirumalaDepartment of Human and Molecular Genetics, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-1318-2072
Li WangDepartment of Human and Molecular Genetics, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0001-9510-6294
Yan LiDepartment of Human and Molecular Genetics, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-1656-3452
Sameer S BajikarDepartment of Human and Molecular Genetics, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-8868-881X
Ashley G AndersonDepartment of Human and Molecular Genetics, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0001-9650-1130
Wei WangDepartment of Human and Molecular Genetics, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-5500-6712
Alexander J TrostleJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX 77030, USA.
Mahla ZahabiyonDepartment of Human and Molecular Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Aleksandar BajicDepartment of Human and Molecular Genetics, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-1255-9835
Jean J KimDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0003-4709-262X
Hu ChenJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX 77030, USA.ORCID 0000-0001-5472-7158
Zhandong LiuJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX 77030, USA.ORCID 0000-0002-7608-0831
Huda Y ZoghbiDepartment of Human and Molecular Genetics, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-0700-3349

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Suzanne AW Fuqua · 2007 to 2026
$73.9M
Preclinical and Clincial OutcomesP50HD103555 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI Sandesh Chakravarthy Sreenath Nagamani, David Loren Nelson · 2020 to 2026
$9.9M
MOLECULAR PATHOGENESIS STUDIES OF RETT SYNDROMER01NS057819 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI ZOGHBI, HUDA Y · 2006 to 2025
$7.5M
Examining adult hippocampal neurogenesis and cognitive function in Rett syndromeF32NS122920 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI ANDERSON, ASHLEY GRACE · 2022 to 2023
$139k
NanoCellect WOLF Cell Sorter and N1 Single-Cell Dispenser SystemS10OD028591 · OD · BAYLOR COLLEGE OF MEDICINE · PI KIM, JEAN J · 2020 to 2020
$108k
Howard Hughes Medical InstituteNCI NIH HHS P30 CA125123NICHD NIH HHS P50 HD103555NIH HHS S10 OD028591NINDS NIH HHS F32 NS122920NINDS NIH HHS R01 NS057819
6 · The paper itself

Abstract

Rett syndrome (RTT) is a neurological disorder caused by loss-of-function mutations in methyl-CpG-binding protein 2 (

Indexed as

Alternative SplicingMethyl-CpG-Binding Protein 2Rett SyndromeAnimalsExonsHumansInduced Pluripotent Stem CellsMiceMutationNeuronsProtein IsoformsRNA, MessengerMethyl-CpG-Binding Protein 2Protein IsoformsRNA, Messenger

Identifiers

PMID41779872
PMCPMC13061089

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.