Evidence map›Paper›PMID 41779856›Full record

ArticleScience advances2026

Vγ1 γδ T cells steer airway macrophages toward a profibrotic response in an autochthonous lung cancer mouse model.

Ximena L Raffo-Iraolagoitia, Amanda J McFarlane, Sarah Laing, Ryan Corbyn, Lindsey W G Arnott, Frédéric Fercoq, Lynn McGarry, Judith Secklehner, Marco De Donatis, John B G Mackey and 14 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. γδ T cells and cancer.The Journal of clinical investigation · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Ximena L Raffo-IraolagoitiaCancer Research UK Scotland Institute, Glasgow, UK.ORCID 0000-0002-8891-4821
Amanda J McFarlaneCancer Research UK Scotland Institute, Glasgow, UK.
Sarah LaingSchool of Cancer Sciences, University of Glasgow, Glasgow, UK.ORCID 0000-0003-3761-5749
Ryan CorbynCancer Research UK Scotland Institute, Glasgow, UK.ORCID 0000-0002-6488-0495
Lindsey W G ArnottCancer Research UK Scotland Institute, Glasgow, UK.
Frédéric FercoqCancer Research UK Scotland Institute, Glasgow, UK.ORCID 0000-0002-4825-024X
Lynn McGarryCancer Research UK Scotland Institute, Glasgow, UK.ORCID 0000-0002-7055-2615
Judith SecklehnerCancer Research UK Scotland Institute, Glasgow, UK.ORCID 0000-0003-0005-3535
Marco De DonatisCancer Research UK Scotland Institute, Glasgow, UK.ORCID 0000-0003-2951-5844
John B G MackeyCancer Research UK Scotland Institute, Glasgow, UK.ORCID 0000-0002-2189-5590
Bjorn KruspigSchool of Cancer Sciences, University of Glasgow, Glasgow, UK.ORCID 0000-0002-1712-5411
Robert WiesheuCancer Research UK Scotland Institute, Glasgow, UK.ORCID 0000-0002-2079-4413
Ya-Ching HsiehSchool of Cancer Sciences, University of Glasgow, Glasgow, UK.
Robin ShawCancer Research UK Scotland Institute, Glasgow, UK.ORCID 0000-0001-5503-5233
Kai RakovicCancer Research UK Scotland Institute, Glasgow, UK.ORCID 0000-0002-0676-1973
John Le QuesneCancer Research UK Scotland Institute, Glasgow, UK.ORCID 0000-0003-3552-7446
Graeme ClarkCancer Research UK Scotland Institute, Glasgow, UK.ORCID 0000-0002-5543-2789
Colin NixonCancer Research UK Scotland Institute, Glasgow, UK.ORCID 0000-0002-8085-2160
Crispin MillerCancer Research UK Scotland Institute, Glasgow, UK.ORCID 0000-0003-4341-1283
Kristina KirschnerCancer Research UK Scotland Institute, Glasgow, UK.ORCID 0000-0001-7607-8670
Calum C BainCentre for Immunobiology, School of Infection and Immunity, University of Glasgow, Glasgow, UK.ORCID 0000-0001-8884-327X
Daniel J MurphyCancer Research UK Scotland Institute, Glasgow, UK.ORCID 0000-0002-5538-5468
Seth B CoffeltCancer Research UK Scotland Institute, Glasgow, UK.ORCID 0000-0003-2257-2862
Leo M CarlinCancer Research UK Scotland Institute, Glasgow, UK.ORCID 0000-0001-7172-5234

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

γδ T cells are important for host defense at the respiratory mucosa, acting directly or through interactions with other cells. However, how γδ T cells influence other immune cells in the lung remains unclear. Using a genetically engineered mouse model of lung cancer, we show that tumors drive expansion of both CD27

Indexed as

Intraepithelial LymphocytesLung NeoplasmsMacrophagesReceptors, Antigen, T-Cell, gamma-deltaT-LymphocytesAnimalsDisease Models, AnimalHumansMiceMice, KnockoutTumor Necrosis Factor Receptor Superfamily, Member 7Receptors, Antigen, T-Cell, gamma-deltaTumor Necrosis Factor Receptor Superfamily, Member 7

Identifiers

PMID41779856
PMCPMC12959402

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.