ArticleProceedings of the National Academy of Sciences of the United States of America2026
Inhibition of FicD-mediated AMPylation and deAMPylation by isoprenoid diphosphates.
Aubrie M Blevins, Wei Peng, Lisa N Kinch, Zihan Monshad, Andrea G Paredes, Christina Volz, Jared Rutter, Amanda K Casey, Kevin G Hicks, Kim Orth
Abstract read
In one paragraphArticle in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
10 authors.
Aubrie M BlevinsDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Wei PengDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Lisa N KinchDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0003-3041-2615 Zihan MonshadDepartment of Biochemistry, University of Utah, Salt Lake City, UT 84112.
Andrea G ParedesDepartment of Biochemistry, University of Utah, Salt Lake City, UT 84112.
Christina VolzDepartment of Biochemistry, University of Utah, Salt Lake City, UT 84112.
Jared RutterDepartment of Biochemistry, University of Utah, Salt Lake City, UT 84112.
Amanda K CaseyDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0002-5829-748X Kevin G HicksDepartment of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT 84112.
Kim OrthDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0002-0678-7620 Funding
UT Southwestern NORCP30DK127984 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Jeffrey M Zigman · 2022 to 2026
$7.4MMitochondrial Biochemistry: From Mechanisms to DiseaseR35GM131854 · NIGMS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jared P Rutter · 2019 to 2026
$3.3MBiochemistry, biology and diversity of Fic domainsR35GM134945 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI ORTH, KIM · 2020 to 2024
$1.8MChemistry-Biology Interface T32T32GM127216 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI KOHLER, JENNIFER J, PHILLIPS, MARGARET A. · 2019 to 2023
$754kChan Zuckerberg Initiative (CZI) 10070558 / 51006865NIDDK NIH HHS P30 DK127984NIH HHS R35 GM131854NIH HHS R35 GM134945NIH T32 T32GM127216Once Upon A Time Foundation N?AWelch Foundation (The Welch Foundation) I-1561
6 · The paper itselfAbstract
FicD regulates Unfolded Protein Response (UPR) through reversible AMPylation and deAMPylation of BiP, an HSP70 chaperone and master regulator of the UPR. FicD activity is regulated by endoplasmic reticulum-stress, catalyzing BiP AMPylation under low stress conditions to hold inactive chaperone in reserve. In stressed cells, FicD deAMPylates BiP, acutely increasing its active pool to assist in protein folding. Variants in UPR machinery, including those in the
Indexed as
Adenosine MonophosphateTerpenesHumansMembrane ProteinsNucleotidyltransferasesUnfolded Protein ResponseAdenosine MonophosphateFICD protein, humanMembrane ProteinsNucleotidyltransferasesTerpenesAMPylationFicDisoprenoid diphosphatesPTMunfolded protein response
Identifiers
PMID41779785
PMCPMC12974487
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