ArticleGenes & genomics2026
Comparative analysis of spatial expression patterns of ectopic olfactory receptors.
Article in Genes & genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Ectopic Olfactory Receptors in Oral Health and Disease: Molecular Links Between Chemosensing, Tissue Repair, Inflammation, and Cancer.International journal of molecular sciences · 2026Review
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe oral mucosa comprises anatomically and functionally distinct regions that differ in their degree of keratinization and barrier properties. Ectopic olfactory receptors (OR) have been detected in the oral mucosa. However, their expression patterns and potential roles remain poorly understood.
objectiveThis study aimed to characterize the molecular features and regional differences of structurally and functionally distinct oral mucosal tissues through unbiased transcriptomic analysis, and to explore the potential involvement of ectopic ORs as chemosensory components within this context.
methodsGingival, buccal, and palatal mucosal tissues were collected by full-thickness excision from 8-week-old adult mice. Total RNA was extracted and sequenced. Differentially expressed genes (DEGs) and expression patterns were analyzed via bioinformatic approaches, and selected genes were validated by RT-qPCR.
resultsBuccal, gingival, and palatal epithelia exhibited distinct transcriptional profiles, with gingiva and palate showing higher mutual correlation compared with buccal mucosa. Buccal tissue was enriched for genes associated with muscle activity and cytoskeletal organization, whereas genes related to keratinization and epithelial differentiation related genes were relatively underrepresented. Pairwise differential expression analysis indicated greater molecular divergence between buccal and masticatory mucosa than between gingiva and palate. Pattern-based transcriptomic analysis defined a global expression topology across oral mucosal tissues, in which ectopic ORs and associated genes were nonrandomly distributed. Several ORs displayed tissue-biased expression patterns linked to keratinization, calcium signaling, and GPCR-related pathways.
conclusionThese findings demonstrate that buccal, gingival, and palatal epithelia constitute transcriptionally and functionally distinct compartments of the oral mucosa. The regional embedding of ectopic ORs within tissue-specific expression architecture suggests a potential role for chemosensory mechanisms in shaping site-specific physiological responses, providing a molecular framework for understanding chemical sensing in the oral mucosa.
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Registered trials
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