ReviewOdontology2026
Impact of adjunctive melatonin in periodontal therapy on glycated hemoglobin levels in patients with type 2 diabetes and periodontal disease: a systematic review and meta-analysis.
Review in Odontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Melatonin has demonstrated anti-inflammatory, antioxidant, and immunomodulatory properties, making it a potential adjunct in periodontal therapy. However, its systemic metabolic effects, particularly on glycemic control in patients with type 2 diabetes mellitus (T2DM) and periodontitis, remain unclear. Aim To evaluate the impact of adjunctive melatonin in nonsurgical periodontal therapy on glycated hemoglobin (HbA1c) levels in patients with T2DM and periodontitis. Materials and Methods: A systematic search was conducted in PubMed, EMBASE, and the Cochrane Library through July 2025. Randomized controlled trials comparing scaling and root planing (SRP) with adjunctive melatonin versus SRP alone or with placebo were included. The primary outcome was the change in HbA1c levels. Data were pooled using a random-effects model in Review Manager 5.4, and risk of bias was assessed using the Cochrane RoB 2 tool. Results: Of 79 records screened, 3 randomized controlled trials (214 participants) met the eligibility criteria. Meta-analysis revealed a significant reduction in HbA1c levels with adjunctive melatonin compared to control (Mean Difference: - 1.08%; 95% CI: - 1.61 to - 0.55; p < 0.0001), despite substantial heterogeneity (I
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.