Evidence map›Paper›PMID 41779233›Full record

ReviewMolecular biology reports2026

Decoding the modulatory role of long non-coding RNAs in embryogenesis: a comprehensive review.

Ahmed A El-Husseiny, Sara M Sayed, Nada S Ali, Morkoss M Fakhry, Rowyda M Salman, Mohamed A Haroun, Mona S Awed

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ahmed A El-HusseinyBiochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, Cairo, 11231, Egypt. ahmedabdullah1984@azhar.edu.eg.ORCID http://orcid.org/0000-0003-0153-6555
Sara M SayedBiochemistry and Molecular Biology Department, Faculty of Pharmacy (Girls), Al-Azhar University, Nasr City, Cairo, Egypt.
Nada S AliDepartment of Biochemistry, Faculty of Pharmacy, Egyptian Russian University, Badr City, Cairo, 11829, Egypt.
Morkoss M FakhryDepartment of Biochemistry, Faculty of Pharmacy, Egyptian Russian University, Badr City, Cairo, 11829, Egypt.
Rowyda M SalmanDepartment of Biochemistry, Faculty of Pharmacy, Egyptian Russian University, Badr City, Cairo, 11829, Egypt.
Mohamed A HarounDepartment of Obstetrics and Gynecology, Faculty of Medicine, Modern University of Technology and Information, Cairo, Egypt.
Mona S AwedDepartment of Biochemistry, Faculty of Pharmacy, Egyptian Russian University, Badr City, Cairo, 11829, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Embryogenesis is the highly coordinated process by which a single-celled zygote develops into a complex multicellular organism. It involves tightly regulated events such as cell division, differentiation, migration, and the establishment of body axes and organ systems. Precise control of gene expression is crucial during these stages to ensure proper lineage specification and tissue development. Disruption of these regulatory networks can lead to developmental abnormalities or disease, making embryogenesis a central focus in developmental biology and regenerative medicine. Long non-coding RNAs (lncRNAs) have gained recognition as pivotal regulators of gene expression. Many lncRNAs exhibit cell and stage-specific expressions, underscoring their importance in development, differentiation, and disease. Their functional diversity highlights lncRNAs as crucial regulators of genome activity and potential targets for therapeutic intervention. In embryogenesis, where precise spatiotemporal control of lineage commitment is crucial, lncRNAs act as dynamic modulators of pluripotency, germ layer specification, and tissue differentiation. They influence cellular processes via diverse mechanisms, encompassing cis/trans regulation, epigenetic remodeling of chromatin, transcriptional and post-transcriptional modulation, and the control of signaling cascades. Therefore, this review discusses the latest updates on embryogenesis, with a particular focus on the emerging role of lncRNAs in embryogenesis, lineage differentiation, and developmental gene regulation.

Indexed as

Embryonic DevelopmentRNA, Long NoncodingAnimalsCell DifferentiationCell LineageEpigenesis, GeneticGene Expression Regulation, DevelopmentalHumansSignal TransductionRNA, Long NoncodingEmbryogenesisEpigeneticLncRNAPluripotencyStemness

Identifiers

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.