Evidence map›Paper›PMID 41778916›Full record

ArticleAntimicrobial agents and chemotherapy2026

Model-based quantification of immune response and anti-staphylococcal activity of afabicin in immunocompetent mouse thigh infections to enable predictions of clinical efficacy.

Raphaël Saporta, Elisabet I Nielsen, Annick Menetrey, David R Cameron, Valérie Nicolas-Métral, Lena E Friberg

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Raphaël SaportaDepartment of Pharmacy, Uppsala University, Uppsala, Sweden.ORCID 0009-0005-3459-6839
Elisabet I NielsenDepartment of Pharmacy, Uppsala University, Uppsala, Sweden.ORCID 0000-0003-0725-214X
Annick MenetreyTranslational Medicine Department, Debiopharm International SA, Lausanne, Switzerland.
David R CameronTranslational Medicine Department, Debiopharm International SA, Lausanne, Switzerland.
Valérie Nicolas-MétralTranslational Medicine Department, Debiopharm International SA, Lausanne, Switzerland.
Lena E FribergDepartment of Pharmacy, Uppsala University, Uppsala, Sweden.ORCID 0000-0002-2979-679X

Funding

HORIZON EUROPE Marie Sklodowska-Curie Actions 861323Vetenskapsrådet 2022-00657
6 · The paper itself

Abstract

This study aimed to describe the immune response and activity of the novel antibiotic afabicin against

Indexed as

Anti-Bacterial AgentsStaphylococcal InfectionsStaphylococcus aureusAnimalsDisease Models, AnimalFemaleHumansMiceMicrobial Sensitivity TestsPhagocytosisThighAnti-Bacterial Agentsafabicinimmune responsemodelingmurine thigh infection modelpharmacokinetics-pharmacodynamicsStaphylococcus aureus

Identifiers

PMID41778916
PMCPMC13041350

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.