Evidence map›Paper›PMID 41778915›Full record

ArticleAntimicrobial agents and chemotherapy2026

Directed evolution of the pathogenic mold

Mariana Handelman, Argha Sarkar, Avital Varshavsky, Yona Shadkchan, Xuefei Chen, Gerard D Wright, Endrews Delbaje, Bradley Laflamme, Sara Fallah, Evelyne Côté and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Mariana HandelmanDepartment of Clinical Microbiology and Immunology, Gray School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Argha SarkarDepartment of Clinical Microbiology and Immunology, Gray School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Avital VarshavskyDepartment of Clinical Microbiology and Immunology, Gray School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Yona ShadkchanDepartment of Clinical Microbiology and Immunology, Gray School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Xuefei ChenDavid Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.
Gerard D WrightDavid Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0002-9129-7131
Endrews DelbajeDepartamento de Biologia, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil.
Bradley LaflammeDepartment of Molecular Genetics, University of Toronto, , Toronto, Ontario, Canada.ORCID 0000-0001-8220-8128
Sara FallahDepartment of Molecular Genetics, University of Toronto, , Toronto, Ontario, Canada.
Evelyne CôtéDepartment of Molecular Genetics, University of Toronto, , Toronto, Ontario, Canada.
Nicole RobbinsDepartment of Molecular Genetics, University of Toronto, , Toronto, Ontario, Canada.
Thaila Fernanda Dos ReisDepartamento de Bioquímica, Instituto de Química, Universidade Estadual de São Paulo, Araraquara, Brazil.
Gustavo H GoldmanFaculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil.ORCID 0000-0002-2986-350X
Leah E CowenDepartment of Molecular Genetics, University of Toronto, , Toronto, Ontario, Canada.ORCID 0000-0001-5797-0110
Nir OsherovDepartment of Clinical Microbiology and Immunology, Gray School of Medicine, Tel Aviv University, Tel Aviv, Israel.ORCID 0000-0002-0433-0096

Funding

Deciphering the phenotypic and genomic traits that underlie the evolution of pathogenicity differences among Aspergillus fumigatus and its close relativesR01AI153356 · NIAID · VANDERBILT UNIVERSITY · PI Antonis Rokas · 2022 to 2026
$3.5M
CIHR FDN-154288Fundação de Amparo à Pesquisa do Estado de São Paulo 2021/04977-5Israel Science Foundation 2937/23NIH HHS R01 AI153356
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antifungal AgentsAspergillus fumigatusDrug Resistance, FungalTriazolesCytochrome P-450 Enzyme SystemDirected Molecular EvolutionFungal ProteinsHumansMicrobial Sensitivity TestsMutationVoriconazoleAntifungal Agentscytochrome P-450 CYP51A, AspergillusCytochrome P-450 Enzyme SystemFungal ProteinsTriazolesVoriconazoleAspergillus fumigatusdrug resistanceevolutiontriazole antifungals

Identifiers

PMID41778915
PMCPMC13041316

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.