Evidence map›Paper›PMID 41778805›Full record

ArticlemSystems2026

EEG and gut microbiota response patterns in high-altitude indigenous populations.

Ke Bai, Ting Ge, Chen-Xi Wang, Yi-Yi Dou, Ji-Xuan Zhang, Peng Li, Xiu-Long Feng, Yu Han, Sha-Sha Zhao, Kui-Ming Su and 10 more

Abstract read
In one paragraph

Article in mSystems, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Ke Bai *Department of Radiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China.ORCID 0009-0000-7218-082X
Ting Ge *Department of Radiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China.
Chen-Xi Wang *Department of Radiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China.
Yi-Yi DouDepartment of Radiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China.
Ji-Xuan ZhangDepartment of Radiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China.
Peng LiDepartment of Radiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China.
Xiu-Long FengDepartment of Radiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China.
Yu HanDepartment of Radiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China.
Sha-Sha ZhaoDepartment of Radiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China.
Kui-Ming SuDepartment of Radiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China.
Yu-Xuan ShangDepartment of Radiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China.
Xing YuDepartment of Radiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China.
Si-Rui LiDepartment of Radiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China.
Dan SuDepartment of Radiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China.
Jia-Jie SongDepartment of Radiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China.
Xu QinDepartment of Radiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China.
Jie YuDepartment of Radiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China.
Chang-Bin YangDepartment of Radiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China.ORCID 0009-0007-6172-057X
Jun-Peng ZhangDepartment of Automation, College of Electrical Engineering, Sichuan University, Chengdu, Sichuan, People's Republic of China.ORCID 0000-0002-9478-8243
Wen WangDepartment of Radiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China.ORCID 0000-0001-6473-4888

Funding

7T MRI Precision Neurology Platform of Shaanxi Province 2025PT-08Hovering Program of Fourth Military Medical University axjhwwInnovative Team for Early Warning and Rehabilitation of Mental Fatigue Using BCI and Virtual RealityKey Core Technique Program of Shaanxi Province 2024SF2-GJHX-71Science and Technology Research Project of Shaani Nuclear Industry Group Co., Ltd 61240302Talent Foundation of Tangdu Hospital 2018BJ003Tangdu Hospital, Fourth Military Medical University 2020QZDY002
6 · The paper itself

Abstract

Indigenous high-altitude populations maintain relatively normal brain function despite chronic hypoxia, yet the underlying neurophysiological mechanisms and the potential role of gut-brain interaction remain unclear. This study combined 16S rRNA gut microbiota profiling in 211 high-altitude indigenous populations at 2, 3, and 4 km altitudes with resting-state and task-based electroencephalography recordings in 135 of them. Residents at 4 km showed enhanced delta (1-4 Hz) power across most brain regions along with increased frontal-occipital functional connectivity (FC) during resting state. During a cognitive oddball task, the 4 km group exhibited elevated P3 amplitude in response to oddball stimuli, together with larger parietal delta power. In parallel, the 4 km group displayed higher species richness and an elevated abundance of short-chain fatty acid-producing genera such as

Indexed as

AltitudeBrainElectroencephalographyGastrointestinal MicrobiomeAdultFemaleHumansMaleRNA, Ribosomal, 16SYoung AdultRNA, Ribosomal, 16Sbrain/gut interactionelectroencephalography (EEG)gut microbiotahigh altitude

Identifiers

PMID41778805
PMCPMC13011389

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.