Evidence map›Paper›PMID 41778753›Full record

ArticleJournal of medicinal chemistry2026

Interaction of Cytochrome P450 3A4 with Fatty Acid Binding Protein 1 and Relevance to Drug Metabolism.

Kevin D McCarty, Destiny L D Proffett, F Peter Guengerich

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kevin D McCartyFrom the Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States.ORCID 0000-0003-0027-9120
Destiny L D ProffettFrom the Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States.
F Peter GuengerichFrom the Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States.ORCID 0000-0002-7458-3048

Funding

Metabolism of Carcinogens and Drugs by Human P450sR01GM118122 · NIGMS · VANDERBILT UNIVERSITY · PI GUENGERICH, F PETER · 2016 to 2023
$3.3M
Functional Roles of Human Cytochrome P450 EnzymesR35GM151905 · NIGMS · VANDERBILT UNIVERSITY · PI F PETER Guengerich · 2024 to 2026
$1.3M
NIGMS NIH HHS R01 GM118122NIGMS NIH HHS R35 GM151905
6 · The paper itself

Abstract

Liver fatty acid binding protein (FABP1) is an abundant cytosolic component that interacts with drugs and can transfer substrates to cytochrome P450 enzymes (P450s, CYPs). FABP1 bound the P450 3A4 substrates diazepam and sulfinpyrazone with

Indexed as

Cytochrome P-450 CYP3AFatty Acid-Binding ProteinsHumansKineticsMicrosomes, LiverOxidation-ReductionProtein BindingCYP3A4 protein, humanCytochrome P-450 CYP3AFABP1 protein, humanFatty Acid-Binding Proteins

Identifiers

PMID41778753
PMCPMC13036779

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.