ArticleJournal of the American Heart Association2026
Severity of Intracranial Arterial Calcification on Computed Tomography and Risk of Dementia in Patients With Stroke or Transient Ischemic Attack: A Population-Based Study.
Article in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Intracranial Arterial Calcification on Computed Tomography and Risk of Cognitive Impairment or Dementia: A Systematic Review and Meta-Analysis.Cerebrovascular diseases (Basel, Switzerland) · 2026Pooled it
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCoronary arterial calcification predicts coronary events, but although intracranial arterial calcification on CT (CT-IAC) is a frequent finding in older individuals, few longitudinal studies have assessed whether its severity or site predict dementia. We did a population-based study in patients with transient ischemic attack (TIA) or stroke to assess these associations.
methodsIn a matched case-control study of patients with minor stroke/transient ischemic attack nested in the population-based OXVASC (Oxford Vascular Study), severity (qualitatively and semiautomated volume) and location (intimal or internal elastic lamina) of CT-IAC in cases who developed dementia on follow-up was compared with that in age-/sex-matched controls who did not (logistic regression adjusted for other risk factors).
resultsIn OXVASC (cases/controls=200/200; mean age=78.0±9.3 years), dementia was independently associated with severity of internal carotid artery CT-IAC on visual assessment (bilateral severe-adjusted OR [aOR], 2.02 [95% CI, 1.26-3.23],
conclusionsSeverity of CT-IAC independently predicts future dementia after stroke/ transient ischemic attack. The extent of any nonlinearity and calcification- or dementia-subtype differences should be determined in larger studies.
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