ArticleArchives of Iranian medicine2025
Necrotizing Enterocolitis in Term Neonates: A Retrospective Chart Review from Children's Medical Center, Tehran (2020-2023).
Article in Archives of Iranian medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundNecrotizing enterocolitis (NEC) is one of the most life-threatening conditions affecting neonates admitted to the neonatal intensive care unit (NICU). Prematurity and low birth weight are the most widely recognized risk factors. However, NEC can also occur in term neonates. This study investigated the incidence, clinical presentation, and underlying medical conditions associated with NEC in term neonates at a tertiary referral children's hospital in Tehran, Iran.
methodsA retrospective review was conducted on term neonates diagnosed with NEC from 2020 to 2023. Data were collected on demographics, clinical presentation, laboratory findings, underlying medical conditions, treatment, and outcomes.
resultsOf 975 term neonates admitted to the NICU during the study period, 33 were diagnosed with NEC, yielding an incidence of 3.38% (95% CI: 2.33-4.72). The mean birth weight was 3.15±0.57 kg, and NEC symptoms appeared at a mean age of 18.3±8.1 days. Abdominal distention was the most common initial symptom (78.8%). A history of herbal medication intake was reported significantly higher compared to non-NEC term neonates (
conclusionThis study highlights a notable incidence of NEC among term neonates in a tertiary Iranian NICU and identifies herbal medication intake as a potential risk factor. These findings underscore the importance of early recognition and culturally sensitive preventive strategies in term infants, especially in regions where herbal remedies are commonly used.
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