ArticleArchives of Iranian medicine2025
Primary Pediatric Brain Tumors in a Tertiary Referral Center in Iran: A 13-Year Retrospective Analysis.
Article in Archives of Iranian medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPediatric central nervous system (CNS) tumors are among the most common childhood malignancies and a leading cause of cancer-related death. This study aimed to describe the histopathological spectrum of primary brain tumors in children over a 13-year period in a tertiary referral center in Iran.
methodsIn this existing data study (EDS), we reviewed the medical records of 549 patients aged 0-17 years who underwent surgical resection of brain tumors between 2008 and 2020. Tumor characteristics, including histology, location, and World Health Organization (WHO 2016) grade, along with patient age and sex, were extracted. Descriptive and comparative analyses were conducted. Temporal trends for single-center in the number of pediatric brain tumor surgeries performed in our center were assessed using Poisson regression.
resultsThe mean age at diagnosis was 5.1 years, with a male-to-female ratio of 1.3:1. Pilocytic astrocytoma (20.9%) was the most common tumor, followed by medulloblastoma (15.3%) and ependymoma (11.3%). Tumors were nearly evenly distributed between supratentorial (48.6%) and infratentorial (48.5%) regions. Grade I tumors were most frequent overall, while Grade IV tumors were significantly more common in the infratentorial space (
conclusionThis single-center study provides institutional-level insights into the histopathological characteristics of pediatric brain tumors. The predominance of low-grade tumors observed emphasizes the need for national pediatric neuro-oncology registries, particularly in low- and middle-income countries, to enable more representative data collection and planning.
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