ReviewEpigenetics2026
Emerging roles of RNA N5-methylcytosine modification in reproductive physiology and gynecological diseases.
Review in Epigenetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- NSUN2-Mediated mAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- 5-Methylcytidine RNA Epitranscriptomics in Women's Health and Disease: Mechanisms and Clinical Implications.Cells · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The epitranscriptome, comprising post-transcriptional RNA modifications, has emerged as a pivotal regulator of gene expression in the female reproductive system. Among these modifications, 5-methylcytosine (m5C) stands out as a widespread and highly conserved mark whose roles in female reproductive health and disease are increasingly recognized but have not yet been systematically summarized. This review aims to synthesize current knowledge on the functions and regulatory mechanisms of m5C in female reproductive physiology and associated pathologies. We begin with a foundational overview of m5C, detailing its definition, biological functions, and the dynamic regulatory network of 'writers,' 'readers,' and 'erasers.' We then examine the critical roles of m5C in key physiological processes, including oogenesis and early embryonic development. Furthermore, we provide an in-depth analysis of the mechanistic involvement and clinical implications of m5C dysregulation in various gynecological diseases. By consolidating recent advances, this review seeks to establish a comprehensive framework for understanding m5C in the female reproductive system and to offer a valuable reference and theoretical basis for future research and therapeutic exploration.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.