Evidence map›Paper›PMID 41778383›Full record

ArticleJournal of materials chemistry. B2026

Synthesis and characterization of an injectable telechelic material for the epiretinal delivery of retinal gene therapies.

James H Westbay, Daniel P Bigley, Sushma Sappa, Anfisa Ayalon, Hamzah Aweidah, Lauren D Dignam, Joseph N Martel, William A Beltran, José-Alain Sahel, Leah C Byrne and 1 more

Abstract read
In one paragraph

Article in Journal of materials chemistry. B, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

James H WestbayDepartment of Ophthalmology, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA. morgandileo@pitt.edu.ORCID http://orcid.org/0000-0003-2023-8721
Daniel P BigleyDepartment of Ophthalmology, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA. morgandileo@pitt.edu.
Sushma SappaDepartment of Ophthalmology, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA. morgandileo@pitt.edu.
Anfisa AyalonDepartment of Ophthalmology, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA. morgandileo@pitt.edu.
Hamzah AweidahDepartment of Ophthalmology, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA. morgandileo@pitt.edu.
Lauren D DignamDepartment of Ophthalmology, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA. morgandileo@pitt.edu.
Joseph N MartelDepartment of Ophthalmology, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA. morgandileo@pitt.edu.
William A BeltranDivision of Experimental Retinal Therapies, Department of Clinical Sciences & Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
José-Alain SahelDepartment of Ophthalmology, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA. morgandileo@pitt.edu.
Leah C ByrneDepartment of Ophthalmology, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA. morgandileo@pitt.edu.
Morgan V DiLeoDepartment of Ophthalmology, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA. morgandileo@pitt.edu.

Funding

Virus Production and Manipulation of Protein/Gene Expression ModuleP30EY008098 · NEI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Yuanyuan Chen · 1989 to 2026
$17.8M
Interdisciplinary Visual Sciences (IVS) Traininig ProgramT32EY017271 · NEI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Marlene Behrmann, Paul R. Kinchington · 2008 to 2026
$3.6M
Retinal-adhesive thermoresponsive gel for AAV-mediated gene delivery to the outer retinaR01EY033049 · NEI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BELTRAN, WILLIAM A., BYRNE, LEAH · 2022 to 2025
$2.7M
NEI NIH HHS P30 EY008098NEI NIH HHS R01 EY033049NEI NIH HHS T32 EY017271
6 · The paper itself

Abstract

There is a need to develop safer, more efficient, and targeted strategies for the delivery of retinal gene therapies. Current strategies may require high dose therapeutics administered intravitreally or complex subretinal surgical delivery with increased risks. An optimized material carrier could enable localized delivery of therapeutics without extensive surgery. Here, we report a novel material carrier formed by octadecane-poly(ethylene glycol)-octadecane (OPO) molecules. OPO molecules were synthesized

Indexed as

Genetic TherapyGene Transfer TechniquesPolyethylene GlycolsRetinaAnimalsDependovirusGene Therapy AgentsHumansPolyethylene Glycols

Identifiers

PMID41778383
PMCPMC12958304

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.