Synthesis in Stroke, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
31 authors.
Neshika SamarasekeraInstitute for Neuroscience and Cardiovascular Research (N. Samarasekera, G.M., T.J.M., M.A.R., R.A.-S.S.), The University of Edinburgh, United Kingdom.ORCID 0000-0001-6840-0199
Sharon TuckEdinburgh Clinical Trials Unit, Usher Institute (S.T., C.J.W., R.A.-S.S.), The University of Edinburgh, United Kingdom.ORCID 0000-0002-6186-6794
Xia WangThe George Institute for Global Health, Faculty of Medicine (X.W., C.S.A., R.A.-S.S.), University of New South Wales, Sydney, Australia.ORCID 0000-0002-1684-7076
Craig S AndersonThe George Institute for Global Health, Faculty of Medicine (X.W., C.S.A., R.A.-S.S.), University of New South Wales, Sydney, Australia.ORCID 0000-0002-7248-4863
Alireza ShirazianDepartment of Neurology, University of Chicago Medical Center, IL (A.S.).ORCID 0000-0002-6029-6822
Bastian VolbersDepartment of Neurology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnbergt Erlangen-Nrnberg, Germany (B.V., H.B.H.).ORCID 0000-0003-0453-1530
Hagen B HuttnerDepartment of Neurology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnbergt Erlangen-Nrnberg, Germany (B.V., H.B.H.).ORCID 0000-0002-0992-8871
Sarah MarchinaDepartment of Neurology, Beth Israel Deaconess Medical Center, Stroke Division, Boston, MA (S.M., C.N., M.S.).ORCID 0000-0002-9969-9362
Casey NortonDepartment of Neurology, Beth Israel Deaconess Medical Center, Stroke Division, Boston, MA (S.M., C.N., M.S.).ORCID 0009-0002-3361-6365
Magdy SelimDepartment of Neurology, Beth Israel Deaconess Medical Center, Stroke Division, Boston, MA (S.M., C.N., M.S.).ORCID 0000-0002-1936-3173
Kevin ShethDepartment of Neurology, Yale University School of Medicine, New Haven, CT (K.S., G.J.F.).ORCID 0000-0003-2003-5473
Guido J FalconeDepartment of Neurology, Yale University School of Medicine, New Haven, CT (K.S., G.J.F.).ORCID 0000-0002-6407-0302
Pedro CastroDepartment of Clinical Neurosciences and Mental Health, Faculty of Medicine, University of Porto, Portugal (P.C.).ORCID 0000-0003-1401-2398
Grant MairInstitute for Neuroscience and Cardiovascular Research (N. Samarasekera, G.M., T.J.M., M.A.R., R.A.-S.S.), The University of Edinburgh, United Kingdom.ORCID 0000-0003-2189-443X
Tom J MoullaaliInstitute for Neuroscience and Cardiovascular Research (N. Samarasekera, G.M., T.J.M., M.A.R., R.A.-S.S.), The University of Edinburgh, United Kingdom.ORCID 0000-0002-6786-3623
Mark A RodriguesInstitute for Neuroscience and Cardiovascular Research (N. Samarasekera, G.M., T.J.M., M.A.R., R.A.-S.S.), The University of Edinburgh, United Kingdom.ORCID 0000-0002-4507-6872
Adrian Parry-JonesGeoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, Northern Care Alliance NHS Foundation Trust & University of Manchester, United Kingdom (A.P.-J.).ORCID 0000-0002-4462-3846
Nikola SpriggStroke Trials Unit, Mental Health and Clinical Neuroscience, University of Nottingham, Queens Medical Centre Hospital Campus, United Kingdom (N. Sprigg).ORCID 0000-0002-5871-8168
Floris H B M SchreuderDepartment of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, the Netherlands (F.H.B.M.S.).ORCID 0000-0002-7815-0207
Thorsten SteinerDepartment of Neurology, Klinikum Frankfurt Höchst, Germany (T.S.).ORCID 0000-0002-5080-8222
Ken S ButcherSchool of Clinical Medicine (K.S.B.), University of New South Wales, Sydney, Australia.ORCID 0000-0002-0590-7918
Daniel HanleyDivision of Brain Injury Outcomes, Johns Hopkins University, Baltimore, MD (D.H., W.Z.).ORCID 0000-0002-9536-4258
Andrew DemchukDepartment of Clinical Neurosciences and Radiology, Hotchkiss Brain Institute, University of Calgary, Alberta, Canada (A.D.).ORCID 0000-0002-4930-7789
David Rodriguez-LunaDepartment of Neurology, Vall d'Hebron University Hospital, Barcelona, Spain (D.R.-L.).ORCID 0000-0001-8053-4536
Ramon Iglesias ReyNeuroimaging and Biotechnology Laboratory (NOBEL), Clinical Neurosciences Research Laboratory, Health Research Institute of Santiago de Compostela, Spain (R.I.R., P.H.).ORCID 0000-0002-9985-9135
Pablo HervellaNeuroimaging and Biotechnology Laboratory (NOBEL), Clinical Neurosciences Research Laboratory, Health Research Institute of Santiago de Compostela, Spain (R.I.R., P.H.).ORCID 0000-0003-1249-6333
Atte MeretojaDepartment of Neurology, Helsinki University Hospital, Finland (A.M.).ORCID 0000-0001-6433-1931
Aaron M GusdonDepartment of Neurosurgery, University of Texas Health Science Center, McGovern School of Medicine, Houston (A.M.G.).ORCID 0000-0002-3350-6601
Christopher J WeirEdinburgh Clinical Trials Unit, Usher Institute (S.T., C.J.W., R.A.-S.S.), The University of Edinburgh, United Kingdom.ORCID 0000-0002-6494-4903
Rustam Al-Shahi SalmanInstitute for Neuroscience and Cardiovascular Research (N. Samarasekera, G.M., T.J.M., M.A.R., R.A.-S.S.), The University of Edinburgh, United Kingdom.ORCID 0000-0002-2108-9222
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itself
Abstract
backgroundPerihematomal edema (PHE) after intracerebral hemorrhage (ICH) is a biomarker of secondary brain injury. We aimed to determine the direction, strength, and temporality of the association between PHE and functional outcome after ICH onset.
methodsWe did a systematic review to identify cohort studies or trials that used brain computed tomography (CT) imaging to diagnose ICH, and measured functional outcome. We sought individual participant data if they had a diagnostic CT within 72 hours, a repeat CT within 14 days of the diagnostic scan, and were not treated with surgery or therapy that could affect PHE. We did a 2-stage individual participant data meta-analysis. The primary analysis was the association between the change in absolute PHE volume between the diagnostic CT and repeat CT and the primary outcome of death or dependence (modified Rankin Scale score, 3-6) at 90±14 days after ICH onset. We quantified the association between change in absolute PHE volume at 2 repeat CT time points (24±12 and 72±12 hours) and outcome, both unadjusted and adjusted for age, sex, ICH volume on the diagnostic CT, and intraventricular extension using multivariable logistic regression.
resultsFrom 12 969 studies, 38 were eligible, of which 12 studies (with 1 unpublished cohort and the VISTA [Virtual International Stroke Trials Archive]-ICH databank) provided data. We included 1523 participants, of whom 1347 participants (516 [38%] participants female; median age, 66 [interquartile range, 55-75] years) had repeat CT at 24±12 hours, and 495 (195 [39%] participants female; median age, 66 [interquartile range, 55-74] years) had repeat CT at 72±12 hours. 319 participants contributed to both analyses. Death or dependence was associated with absolute PHE growth both in the first 24±12 hours (unadjusted odds ratio, 1.04 per mL increase [95% CI, 1.01-1.06];
conclusionsPHE growth within 24 and 72 hours of ICH onset is independently associated with death or dependence after ICH.
Indexed as
Brain EdemaCerebral HemorrhageRecovery of FunctionAgedFemaleHumansMaleMiddle AgedTomography, X-Ray Computedbiomarkersbraincerebral hemorrhageedematomography
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Perihematomal Edema and Functional Outcome After Intracerebral Hemorrhage: A Meta-Analysis of Individual Participant Data. · full record | OpenQuestion