Evidence map›Paper›PMID 41778278›Full record

ArticleSmall methods2026

Motorized DNAzymes Drive Enhanced Electrochemical Biosensing for Rapid Bacterial Detection.

Amir Ali Akhlaghi, Sadman Sakib, Roderick MacLachlan, Jinal Manek, Enas Osman, Survanshu Saxena, Ehsan Heydarian Dolatabadi, Jimmy Gu, Yingfu Li, Leyla Soleymani

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Small methods, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Amir Ali AkhlaghiSchool of Biomedical Engineering, McMaster University, Hamilton, Ontario, Canada.
Sadman SakibDepartment of Engineering Physics, McMaster University, Hamilton, Ontario, Canada.
Roderick MacLachlanDepartment of Engineering Physics, McMaster University, Hamilton, Ontario, Canada.
Jinal ManekDepartment of Engineering Physics, McMaster University, Hamilton, Ontario, Canada.
Enas OsmanSchool of Biomedical Engineering, McMaster University, Hamilton, Ontario, Canada.
Survanshu SaxenaSchool of Biomedical Engineering, McMaster University, Hamilton, Ontario, Canada.
Ehsan Heydarian DolatabadiSchool of Biomedical Engineering, McMaster University, Hamilton, Ontario, Canada.
Jimmy GuDepartment of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.
Yingfu LiSchool of Biomedical Engineering, McMaster University, Hamilton, Ontario, Canada.ORCID https://orcid.org/0000-0002-7533-6743
Leyla SoleymaniSchool of Biomedical Engineering, McMaster University, Hamilton, Ontario, Canada.ORCID https://orcid.org/0000-0003-4915-2999

Funding

Canada Research ChairsNatural Sciences and Engineering Research Council of Canada
6 · The paper itself

Abstract

Self-propelled micromotors hold great promise for improving the performance of electrochemical biosensors by overcoming mass transport limitations inherent to target recognition on electrode surfaces. However, the successful integration of micromotors in electrochemical biosensors for the analysis of crude biological samples has remained elusive. In this study, we introduce the Motolyzer, a micromotor-based assay that utilizes DNAzymes for the identification and detection of bacterial targets in crude biological samples. In this system, immobilized DNAzymes are propelled by magnetic-layered micromotors within biological samples. Upon encountering their specific targets, these DNAzymes release redox DNA barcodes, which are subsequently analyzed using electrochemical chips. The Motolyzer significantly enhances the target-to-blank ratio of the biosensor (4.5 times) and achieves a limit-of-detection of 2 × 10

Indexed as

Biosensing TechniquesDNA, CatalyticElectrochemical TechniquesLegionella pneumophilaDNA, Catalyticbiosensors, DNAzymeselectrochemistrylegionella pneumophilamicromotors

Identifiers

PMID41778278
PMCPMC13010228

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.