ArticleCancer diagnosis & prognosis
Immunohistochemical Expression of Endoplasmic Reticulum Stress Markers and their Association With Clinicopathological Characteristics and Survival Outcomes in Endometrial Cancer.
Article in Cancer diagnosis & prognosis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background/Aim: This study aimed to examine the immunohistochemical expression of Inositol-Requiring Enzyme 1 Alpha (IRE1) and Protein Kinase R-like ER Kinase (PERK) immunoreactivity scores (IRS) as emerging biomarkers on key clinicopathologic features and survival outcomes in endometrial cancer (EC). Patients and Methods: Immunoreactive scores (IRS) for IRE1 and PERK were assessed in tumor samples from 73 EC survivors and compared with 20 benign endometrial controls. Associations between IRS values and clinicopathological variables were analyzed. Overall survival (OS) and disease-free survival (DFS) were evaluated using univariable and multivariable Cox proportional hazards models adjusted for age, FIGO stage, and tumor grade. Results: IRE1-IRS and PERK-IRS were significantly higher in EC survivors compared to controls ( Conclusion: IRE1 and PERK expression is up-regulated in endometrial cancer and correlates with selected clinicopathological features, particularly those linked to aggressive disease. However, neither marker demonstrated independent prognostic value for survival outcomes. Further studies are warranted to clarify the role of ER stress pathways in EC biology and their potential implications for risk stratification and targeted therapy.
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