ArticleFrontiers in physiology2026
The mechanisms of energy balance between oxidative phosphorylation and glycolysis in human ovarian granulosa cells.
Article in Frontiers in physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- cGAS-STING Signaling as a Molecular Bridge Between Inflammation, Ovarian Ageing, and Reproductive Failure.International journal of molecular sciences · 2026Review
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10 authors.
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Abstract
Objective: This study investigated the interplay between mitochondrial oxidative phosphorylation and glycolysis in human ovarian granulosa cells by analyzing changes induced by the mitochondrial inhibitor carbonyl cyanide m-chlorophenyl hydrazone (CCCP) and the glycolysis inhibitor bromopyruvic acid (BA). Methods: Mural granulosa cells (mGCs) were isolated from tubal factor infertility patients and cultured. Cells were divided into control, CCCP (10 µM), and BA (0.5 mM) groups. Mitochondrial function was assessed via mitochondrial membrane potential (MMP), reactive oxygen species (ROS), and adenosine triphosphate (ATP) levels. Glycolysis-related gene expression (HIF-1α, GLUT1, LDHA, PFKP) was measured by qRT-PCR after CCCP treatment. Glucose consumption and cell viability (CCK-8 assay) were evaluated in control and CCCP groups at 24, 48, and 72 h. Results: Compared to controls, both CCCP and BA groups exhibited significantly decreased in MMP ( Conclusion: Human mGCs utilize both oxidative phosphorylation and glycolysis for energy metabolism. Inhibition of one pathway triggers compensatory upregulation of the other, indicating collaborative regulation between these pathways to maintain cellular function and follicular homeostasis.
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