Observational studyFrontiers in endocrinology2026
Trends and outcomes of fertility preservation in patients presenting with cancer during pregnancy or postpartum-a longitudinal observational cohort study.
Observational study in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
Objective: The aim of this study was to assess the trends and outcomes of fertility preservation (FP) in women referred for FP counseling and presenting with pregnancy-associated cancer (PAC). Method: This is a prospective cohort study of all patients referred for FP counseling between 2001 and 2024 to the FP program of Karolinska University Hospital, Sweden. Baseline data, age, parity, disease stage, treatment characteristics, and FP methods were retrieved from clinical registries. Results: A total of 50 women with cancer diagnosed coincidentally with pregnancy (79%) or up to 1 year after delivery (21%) were referred for FP counseling. Among them, 30 women chose to proceed with FP; 10 by either hormonal stimulation to freeze eggs/embryos or ovarian tissue cryopreservation (OTC) after abortion/miscarriage, 10 by OTC at delivery, and 9 were planned for FP postpartum. The most common cancers were breast cancer ( Conclusions: Our observations underscore the need to ensure good multidisciplinary communication to inform patients presenting with PAC on the future risk for infertility and on the available FP procedures. As FP has to be applied when the patients are not pregnant, these measures can be planned in connection with a cesarean section, or after completion of cancer treatment. Current guidelines for FP lack specific recommendations for women with PAC, and specialized PAC guidelines also lack specific information on FP. Clinical Trial Registration: ClinicalTrials.gov, identifier NTC04602962.
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