Evidence map›Paper›PMID 41778052›Full record

ArticleMediators of inflammation2026

The Potential Value of Blood Inflammatory Parameters in Diagnosing the Inflammatory Microenvironment and Predicting Fetal Outcomes in Patients With Intrahepatic Cholestasis of Pregnancy.

Jianyi Gao, Ling Li, Huan Huang, Jing Chen, Ruirui Dong, Jing Wang, Gaoying Wang, Rong Wang, Yingxian Shi, Linxia Shuang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mediators of inflammation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jianyi GaoWuxi Maternity and Child Health Care Hospital, Affiliated Women's Hospital of Jiangnan University, Jiangnan University, Wuxi, 214002, China, jiangnan.edu.cn.ORCID https://orcid.org/0000-0002-5077-0033
Ling LiWuxi Maternity and Child Health Care Hospital, Affiliated Women's Hospital of Jiangnan University, Jiangnan University, Wuxi, 214002, China, jiangnan.edu.cn.ORCID https://orcid.org/0009-0009-6804-8143
Huan HuangWuxi Maternity and Child Health Care Hospital, Affiliated Women's Hospital of Jiangnan University, Jiangnan University, Wuxi, 214002, China, jiangnan.edu.cn.ORCID https://orcid.org/0009-0000-6952-277X
Jing ChenWuxi Maternity and Child Health Care Hospital, Affiliated Women's Hospital of Jiangnan University, Jiangnan University, Wuxi, 214002, China, jiangnan.edu.cn.ORCID https://orcid.org/0009-0000-1971-6533
Ruirui DongWuxi Maternity and Child Health Care Hospital, Affiliated Women's Hospital of Jiangnan University, Jiangnan University, Wuxi, 214002, China, jiangnan.edu.cn.ORCID https://orcid.org/0000-0003-1970-8968
Jing WangWuxi Maternity and Child Health Care Hospital, Affiliated Women's Hospital of Jiangnan University, Jiangnan University, Wuxi, 214002, China, jiangnan.edu.cn.ORCID https://orcid.org/0000-0001-6882-7520
Gaoying WangWuxi Maternity and Child Health Care Hospital, Affiliated Women's Hospital of Jiangnan University, Jiangnan University, Wuxi, 214002, China, jiangnan.edu.cn.ORCID https://orcid.org/0000-0001-5643-7795
Rong WangWuxi Maternity and Child Health Care Hospital, Affiliated Women's Hospital of Jiangnan University, Jiangnan University, Wuxi, 214002, China, jiangnan.edu.cn.ORCID https://orcid.org/0009-0007-4718-6649
Yingxian ShiWuxi Maternity and Child Health Care Hospital, Affiliated Women's Hospital of Jiangnan University, Jiangnan University, Wuxi, 214002, China, jiangnan.edu.cn.ORCID https://orcid.org/0009-0001-3835-108X
Linxia ShuangWuxi Maternity and Child Health Care Hospital, Affiliated Women's Hospital of Jiangnan University, Jiangnan University, Wuxi, 214002, China, jiangnan.edu.cn.ORCID https://orcid.org/0009-0000-8034-6754
Xiaojin YangWuxi Maternity and Child Health Care Hospital, Affiliated Women's Hospital of Jiangnan University, Jiangnan University, Wuxi, 214002, China, jiangnan.edu.cn.ORCID https://orcid.org/0009-0007-7821-6492
Ting ZhangWuxi Maternity and Child Health Care Hospital, Affiliated Women's Hospital of Jiangnan University, Jiangnan University, Wuxi, 214002, China, jiangnan.edu.cn.ORCID https://orcid.org/0000-0002-3175-4409
Liang LuoWuxi No.2 People's Hospital, Jiangnan University Medical Center, Jiangnan University, Wuxi, 214001, China, jiangnan.edu.cn.ORCID https://orcid.org/0000-0001-6370-1064

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous studies have indicated that the inflammatory microenvironment in pregnant women may contribute significantly to the development of intrahepatic cholestasis of pregnancy (ICP). However, the exact relationship between inflammatory blood parameters and ICP remains uncertain. This study aims to explore the relationship between serum inflammatory factors, inflammatory scoring indicators, and adverse pregnancy outcomes in ICP. Serum samples were collected after 25 weeks of gestation from women clinically diagnosed with ICP, as well as from gestational age-matched healthy pregnant controls. Cytokine levels were subsequently measured using flow cytometry. Correlation analysis was conducted to explore potential relationships between blood inflammatory parameters and other ICP-related markers. Receiver operating characteristic (ROC) curves were generated to evaluate their predictive performance for adverse pregnancy outcomes. Mendelian randomization (MR) analysis was performed to examine potential causal links between inflammation and ICP development. The results revealed significant differences in serum levels of interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α), and interferon-γ (IFN-γ) between ICP patients and healthy controls. Additionally, inflammatory scoring indicators were significantly elevated in ICP patients. Most inflammatory parameters correlated with liver function indices and showed positive associations with total bile acids (TBAs). ROC analysis demonstrated that combining inflammatory markers with TBA improved the predictive accuracy for preterm birth (area under the ROC curve [AUC]: 0.865) and low fetal weight (AUC: 0.916). MR analysis identified interleukin-2 (IL-2) and TNF-α as potential risk factors for ICP. Based on these findings, blood inflammatory parameters may serve as accessible and cost-effective indicators for understanding the inflammatory microenvironment in ICP and predicting fetal outcomes.

Indexed as

Cholestasis, IntrahepaticInflammationPregnancy ComplicationsAdultBiomarkersCase-Control StudiesCytokinesFemaleHumansInterferon-gammaInterleukin-10Interleukin-6PregnancyPregnancy OutcomeROC CurveTumor Necrosis Factor-alphaBiomarkersCytokinesInterferon-gammaInterleukin-10Interleukin-6Tumor Necrosis Factor-alphaadverse pregnancy outcomecytokineinflammatory parametersintrahepatic cholestasis of pregnancyMR analysis

Identifiers

PMID41778052
PMCPMC12951356

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.