ArticleFrontiers in medicine2026
Retrospective analysis of the clinical features of 12 cases of MOG antibody-associated aseptic meningitis.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: In recent years, MOG antibody-associated aseptic meningitis has gradually been reported, but its clinical features are not yet well defined. Methods: A retrospective analysis was conducted on 67 children diagnosed with MOG antibody-associated diseases and treated at the Affiliated Children's Hospital of Shandong University from January 2021 to June 2024. Out of these cases, 12 exhibited aseptic meningitis. The key features of their clinical manifestations, blood cell analysis, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) levels, cerebrospinal fluid (CSF)-related tests, and cranial MRI results were summarized for these 12 cases. Results: A total of 12 cases (100%) presented with prolonged fever as the main clinical feature. Routine blood tests revealed the following: white blood cell counts ranging from 15.92 to 34.0 × 10 Conclusion: These findings highlight that MOG antibody-associated aseptic meningitis primarily manifests as prolonged fever, with peripheral inflammatory markers that mimic a severe bacterial infection, while CSF profiles resemble those of viral encephalitis. Clinicians should consider MOG antibody-associated disorders in children with unexplained recurrent fever.
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