ReviewFrontiers in medicine2026
Impact of hospital sepsis case volume on mortality in sepsis patients: a meta-analysis.
Review in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Evidence regarding the impact of annual hospital sepsis case volume on clinical outcomes in patients with sepsis remains controversial. This study aimed to conduct a meta-analysis to evaluate the potential association between annual sepsis case volume and mortality among patients with sepsis. Methods: A comprehensive electronic search was performed in PubMed, Web of Science, Embase, and Cochrane Library databases. Mean differences (MDs) or odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using Review Manager 5.3. Results: A total of 4,408,416 patients from 18 studies were included in this meta-analysis, comprising 1,828,689 patients treated in high-volume hospitals and 2,579,727 patients treated in low-volume hospitals. Compared with low-volume hospitals, treatment in high-volume hospitals was associated with significantly lower in-hospital mortality [OR = 0.90 (95% CI: 0.87-0.93, Conclusions: Hospitals with a high annual sepsis case volume are associated with reduced mortality among patients with sepsis. Future studies are warranted to further define clinically meaningful thresholds for high-volume hospitals.
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