ArticleFrontiers in transplantation2026
The risk of kidney transplant graft loss in sensitized vs. unsensitized patients is modified by prior transplant status.
Article in Frontiers in transplantation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: A prior kidney transplant (KT) has been associated with an increased risk of graft loss following repeat transplantation. This study examined the risk of adverse posttransplant outcomes between patients with and without a prior transplant, depending on sensitization status. Methods: We used propensity score matching to examine the combined exposure of sensitization status [panel-reactive antibody (PRA) 0%, >0%-80%, and >80%] and first/repeat KT as a nested variable in adults across the US [2000-2017; Scientific Registry of Transplant Recipients (SRTR)]. We then used multivariable Cox and logistic regression models to examine the association between the nested variable and death-censored graft loss (DCGL), all-cause graft loss (ACGL), and delayed graft function (DGF). Effect modification between PRA status (20%) and prior KT status was assessed for each outcome. Results: Among 38,660 matched patients, DCGL (adjusted Hazard Ratio (aHR) 1.56, 95% CI 1.47-1.66), ACGL (aHR 1.42, 95% CI 1.35-1.49), and DGF (adjusted Odds Ratio (aOR) 1.89, 95% CI 1.75-2.03) risk was highest with a prior KT and PRA >80% (vs. unsensitized transplant-naïve patients). The risk associated with increased PRA was greater in those with a prior transplant. Prior KT modified the association between increased PRA and DCGL, ACGL, and DGF ( Conclusion: Prior KT status modified the association between PRA and adverse outcomes. Sensitized patients (PRA >80%) with a prior KT faced higher risks of DCGL, ACGL, and DGF compared with sensitized patients without a prior KT.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.