ReviewGastroenterology and hepatology from bed to bench2025
Effect of coffee and coffee extract on liver function test in non-alcoholic fatty liver disease patients, a systematic review and meta-analysis.
Review in Gastroenterology and hepatology from bed to bench, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aim: This study aimed to investigate the effect of coffee or coffee extract on serum ALT and AST levels in patients with non-alcoholic fatty liver disease (NAFLD), by compiling data from randomized controlled trials up to November 2024. Background: NAFLD represents the most prevalent hepatic disorder, characterized by the accumulation of lipids within hepatocytes in the absence of substantial alcohol consumption or viral infections. Effective management relies on lifestyle changes, such as diet and exercise. Recent studies have suggested that coffee consumption may offer liver-protective benefits, potentially helping to reduce serum levels of liver enzymes. Methods: Two researchers conducted an independent search across PubMed, Web of Science, and Scopus, including clinical trials that assessed the effects of coffee or coffee extract on liver function tests (LFTs) in individuals diagnosed with NAFLD. Meta-analysis was carried out using STATA software. Results: After screening titles, abstracts, and full texts, four studies comprising five placebo-treatment pairs were included in the meta-analysis. Coffee or coffee extract did not significantly affect serum ALT (p= 0.45) and AST (p= 0.54) levels. Conclusion: There is insufficient evidence to support the effectiveness of coffee or coffee extract on serum ALT and AST levels. Due to the limited number of studies, small sample sizes, and short follow-up durations, further randomized controlled trials with adequate sample sizes and more extended follow-up periods are recommended.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.