ReviewGastroenterology and hepatology from bed to bench2025
Outcomes after treatment with proton pump inhibitors in patients with ineffective esophageal motility: a systematic review.
Review in Gastroenterology and hepatology from bed to bench, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aim: This systematic review evaluated the effectiveness of proton pump inhibitors (PPIs) in improving manometric parameters in patients with gastroesophageal reflux disease (GERD) diagnosed with Ineffective esophageal motility (IEM). Background: IEM represents the most common esophageal motility disorder among patients with GERD. To date, no treatment has conclusively demonstrated efficacy in restoring esophageal motor function in these individuals. Methods: This systematic review was performed according to the PRISMA guidelines. We conducted comprehensive searches of electronic databases, including PubMed, Embase, and Scopus, until January 2024 to identify relevant randomized and non-randomized controlled trials. Criteria for study inclusion were based on the population, intervention, comparison, and outcome framework. Results: A total of 9 studies met the inclusion criteria, comprising eight non-randomized controlled trials (non-RCTs) and one randomized controlled trial (RCT). Out of 305 recruited patients with a diagnosis of GERD, 185 patients matched the diagnosis of IEM with manometric studies before and after a PPI treatment. PPIs used in the studies included omeprazole, pantoprazole, lansoprazole, and rabeprazole. The duration of treatment ranged from four to twenty-four weeks. Except for one study, there was no statistically significant improvement in manometric parameters following PPI treatment. Conclusion: Evidence from included studies indicates that although PPIs are effective in healing esophagitis, they do not consistently improve esophageal motility, irrespective of the PPI type, dosage, or treatment duration.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.