Evidence map›Paper›PMID 41777916›Full record

ArticleGastroenterology and hepatology from bed to bench2025

Prospective insights into acute cholangitis: microbial patterns, resistance, risk factors, and outcomes.

Elham Ahmed Hassan, Abeer Sharaf El-Din Abdel Rehim, Asmaa Omar Ahmed, Khaled A Khalaf, Nourhan Mostafa Salama, Mohamed Zakaria Abu Rahma

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gastroenterology and hepatology from bed to bench, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Elham Ahmed HassanGastroenterology and Tropical Medicine Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
Abeer Sharaf El-Din Abdel RehimGastroenterology and Tropical Medicine Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
Asmaa Omar AhmedClinical Pathology Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
Khaled A KhalafGastroenterology and Tropical Medicine Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
Nourhan Mostafa SalamaGastroenterology and Tropical Medicine Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
Mohamed Zakaria Abu RahmaGastroenterology and Tropical Medicine Department, Faculty of Medicine, Assiut University, Assiut, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim: This study investigated the microbiological profile, risk factors, antimicrobial resistance, and clinical outcomes in patients with acute cholangitis. Background: Acute cholangitis is a critical infection resulting from biliary obstruction, with risks of sepsis and high mortality. Methods: This prospective study included 105 patients undergoing biliary drainage for acute cholangitis via endoscopic retrograde cholangiopancreatography or percutaneous transhepatic drainage. Bile and blood cultures were collected. Antimicrobial susceptibility testing was performed. In-hospital outcomes were analysed. Results: Bacteriologically confirmed cholangitis was identified in nearly half of the patients, with Gram-negative bacteria predominating in both bile and blood cultures. Conclusion: -negative bacteria are the primary pathogens in acute cholangitis, and the high burden of multidrug resistance is linked to worse clinical outcomes, particularly in patients with malignant obstruction. Ongoing antibiotic stewardship and local resistance are crucial to optimize empiric therapy and improve patient outcomes.

Indexed as

Acute cholangitisAntibiotic resistanceBile cultureMicrobiological profileOutcomes

Identifiers

PMID41777916
PMCPMC12920707

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.