Evidence map›Paper›PMID 41777882›Full record

ArticleFrontiers in immunology2026

Pre-existing activation states shape functional heterogeneity of human Vγ9Vδ2 T cells.

Anna Vyborova, Laia Gasull-Celades, Peter Brazda, Alberto Miranda Bedate, Froso Karaiskaki, Jasper Sanders, Anke Janssen, Trudy Straetemans, Dennis X Beringer, Zsolt Sebestyen and 1 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Anna Vyborova *Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Laia Gasull-Celades *Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Peter Brazda *Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Alberto Miranda Bedate *Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Froso KaraiskakiCenter for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Jasper SandersCenter for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Anke JanssenCenter for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Trudy StraetemansCenter for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Dennis X BeringerCenter for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Zsolt SebestyenCenter for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Jürgen KuballCenter for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

γδ T cells gain increasing attention as carriers for tumor-targeting constructs in therapeutic contexts. However, the failure to fully account for the diversity within the subset has impeded its clinical use so far. We investigated the heterogeneity of the Vγ9Vδ2 T-cell compartment by profiling the function and gene expression of single-cell clones expanded

Indexed as

Lymphocyte ActivationReceptors, Antigen, T-Cell, gamma-deltaT-Lymphocyte SubsetsCells, CulturedGATA3 Transcription FactorHumansInterferon-gammaInterleukin-4GATA3 protein, humanGATA3 Transcription FactorInterferon-gammaInterleukin-4Receptors, Antigen, T-Cell, gamma-deltaATMPcancer immune cell therapygdT cellheterogeneitytranscriptomics

Identifiers

PMID41777882
PMCPMC12950705

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.