ArticleTH open : companion journal to thrombosis and haemostasis2026
Association of Fibrin Clot Characteristics with Development of Ischemic Stroke in Patients with Recently Diagnosed Type 2 Diabetes.
Article in TH open : companion journal to thrombosis and haemostasis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Ischemic stroke occurs when a thrombus blocks a cerebral artery, and an important component is the fibrin clot. Different plasma fibrinogen variants have been associated with stroke risk in type 2 diabetes (T2D). We hypothesized that in vitro fibrin clot characteristics are associated with stroke risk and correlate with fibrinogen variants. Objective: To investigate the association of fibrin clot characteristics with risk of ischemic stroke in T2D and the correlation of fibrinogen variants with clot characteristics. Methods: In a nested case-control study with a median follow-up of 4.1 years, we included 144 T2D patients with ischemic stroke (cases) and 144 matched T2D patients without ischemic stroke (controls). Clot formation (velocity [ Results: Fibrin fiber density at baseline was significantly lower in future stroke cases (4.2 [3.7-4.7] ×10 Conclusion: In our study, turbidimetric fibrin clot characteristics were not convincingly associated with ischemic stroke in T2D. Absolute levels of fibrinogen variants correlated consistently with clot characteristics.
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