ArticleRSC advances2026
Feathered innovation: transforming recycled keratin into bioactive micro/nanoparticles for bioactive keratin-based delivery platform.
Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Biomaterials Mimicking Mechanobiology: A Specific Design for a Specific Biological Application.International journal of molecular sciences · 2024Review
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Authors and funding
6 authors.
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Abstract
At present, great importance is dedicated to the use of waste biomass for the sustainable provision and fractionation of natural resources. This is particularly true for the production of biopolymers to promote the development of novel material products based on sustainability. This growing interest is driven by socioeconomic and environmental factors. Feathers from chickens are regarded as waste from the poultry meat production sector. These organic wastes serve as natural keratin sources for synthesizing nanoparticles to develop a new generation of multifunctional biocomposites for drug delivery purposes. Thus, in this research keratin was isolated from feathers by extraction in subcritical water (SubCW) at 180 °C, 20 bar for 1 h. This recycled keratin was used to develop advanced keratin-based particles. The aim of this study was to explore the potential of subcritically extracted keratin to form electrostatically stabilized particles with different types of interaction agents-namely natural polyelectrolytes and a multivalent ionic crosslinker (TPP)-and to evaluate their performance as a multifunctional keratin-based delivery platform. To investigate the complexation ability of keratin, three polyelectrolytes with different functional groups were used for particle synthesis at specific pH values, namely alginate with carboxyl groups, chitosan with amino groups, and penta-ionic sodium tripolyphosphate (TPP) with phosphate groups. Dynamic Light Scattering (DLS) analysis showed that complex formation between keratin-alginate and keratin-chitosan resulted in microparticles, and colloidal particles were formed only in the case of keratin-TPP. The ATR-FTIR spectra of the particles indicate that electrostatic interactions were the driving force for the complex formation between keratin and oppositely charged polyelectrolytes. The antioxidant activity of keratin diminishes upon the incorporation of alginate, chitosan, and TPP. The keratin-TPP particles, identified as optimal, underwent additional assessment as a keratin-based delivery platform for the model drug amoxicillin. UV/VIS spectroscopy indicated the successful encapsulation of amoxicillin (encapsulation efficiency of 69%), with a gradual release reaching up to 96% over a 6-hours period. Antimicrobial examination showed that the increased inhibition against both
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