ArticleEpilepsy & behavior reports2026
Real-world Data on Adult Status Epilepticus from Latin America: Clinical Characteristics and Outcomes in a Mexican Tertiary Center.
Article in Epilepsy & behavior reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Status epilepticus is a life-threatening emergency in neurology practice. Latin America faces a disproportionate epilepsy burden; little data is available on this population type. Objective: To describe the clinical characteristics, treatment approaches, and functional outcomes of adult patients with SE in a tertiary neurological center in Mexico City. Methods: We conducted a retrospective cohort study involving 103 adult patients diagnosed with SE from 2020 to 2024. Functional outcomes were measured using the modified Rankin Scale (mRS), with scores 0-2 classified as favorable. Severity was assessed with the STESS. Chi-square, Mann-Whitney U tests, and logistic regression were used to identify variables related to outcomes. Results: The median patient age was 36 (IQR 18-79), with 50.5% of patients being female. Most had a prior diagnosis of epilepsy (80.6%). Convulsive SE (74.8%) and acute symptomatic etiologies (70.9%) were predominant. Infections were the leading cause among acute symptomatic cases (35%). Refractory SE occurred in 41.7% of cases, and 14.6% progressed to super-refractory SE. Favorable outcomes were significantly associated with prior epilepsy (p = 0.032), and SE subtype (p = 0.003). Multivariate analysis confirmed prior epilepsy as an independent predictor of good outcome (OR = 0.65, 95% CI 0.48-0.87; p = 0.004). Conclusions: This study offers the most extensive characterization of SE in a Mexican center. Infectious etiologies dominate the clinical landscape, with functional outcome linked to baseline epilepsy history and SE subtype.
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