ArticleFrontiers in neuroscience2026
Effect of curcumin and
Article in Frontiers in neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Objective: Peripheral nerve injury and diabetes can lead to some serious neurodegenerative changes in central nervous system structures. Curcumin and Method: Thirty-five male adult rats were divided into five groups: Control, Sham (Transected Sciatic Nerve), Transected Sciatic Nerve + Diabetes (T + DM), T + DM + Curcumin (T + DM + Cur), and T + DM + Results: Stereological analyses revealed that the volume fraction of the molecular layer was significantly lower in the T + DM + Cur group compared to the T + DM + GK and T + DM groups. A significant decrease in the volume fraction of the Purkinje cell layers was observed in the T + DM + Cur group compared to the Sham group. No significant differences were found between the groups in the granular layer and white matter volume fractions. Immunohistochemical analysis revealed inhibition of caspase-3 activity in the T + DM group. However, intense caspase-3 activation was also observed in the Control and T + DM + Cur groups. Conclusion: Sciatic nerve transection, combined with diabetes, leads to significant structural and cellular changes in the cerebellar cortex. The mechanisms underlying the anti-apoptotic effects of diabetes on granular cells and other cerebellar components should be investigated in detail.
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