Evidence map›Paper›PMID 41777721›Full record

ArticleScientifica2026

Jumriani Jumriani, Muhammad Aswad, Ratnawati Ratnawati, Filmaharani Filmaharani, Anggun Nurhidayah, Muhammad Rayza Azmin, Alfreds Roosevelt, Rizky Alfiana, Widya Hardiyanti, Nadila Pratiwi Latada and 2 more

Abstract read
In one paragraph

Article in Scientifica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Scientifica · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jumriani JumrianiPostgraduate Program in Pharmacy, Faculty of Pharmacy, Hasanuddin University, Tamalanrea, Makassar, 90245, Indonesia, unhas.ac.id.ORCID https://orcid.org/0009-0007-8506-0051
Muhammad AswadDepartment of Pharmaceutical Science and Technology, Faculty of Pharmacy, Hasanuddin University, Tamalanrea, Makassar, 90245, Indonesia, unhas.ac.id.ORCID https://orcid.org/0000-0002-7420-2401
Ratnawati RatnawatiPostgraduate Program in Pharmacy, Faculty of Pharmacy, Hasanuddin University, Tamalanrea, Makassar, 90245, Indonesia, unhas.ac.id.ORCID https://orcid.org/0009-0005-2513-5184
Filmaharani FilmaharaniPostgraduate Program in Pharmacy, Faculty of Pharmacy, Hasanuddin University, Tamalanrea, Makassar, 90245, Indonesia, unhas.ac.id.ORCID https://orcid.org/0009-0009-5192-3992
Anggun NurhidayahPostgraduate Program in Pharmacy, Faculty of Pharmacy, Hasanuddin University, Tamalanrea, Makassar, 90245, Indonesia, unhas.ac.id.ORCID https://orcid.org/0009-0008-2027-7337
Muhammad Rayza AzminPostgraduate Program in Pharmacy, Faculty of Pharmacy, Hasanuddin University, Tamalanrea, Makassar, 90245, Indonesia, unhas.ac.id.ORCID https://orcid.org/0009-0009-2497-5498
Alfreds RooseveltPostgraduate Program in Pharmacy, Faculty of Pharmacy, Hasanuddin University, Tamalanrea, Makassar, 90245, Indonesia, unhas.ac.id.ORCID https://orcid.org/0000-0001-9532-4371
Rizky AlfianaPostgraduate Program in Pharmacy, Faculty of Pharmacy, Hasanuddin University, Tamalanrea, Makassar, 90245, Indonesia, unhas.ac.id.ORCID https://orcid.org/0009-0008-9974-1592
Widya HardiyantiUnhas Fly Research Group, Faculty of Pharmacy, Hasanuddin University, Tamalanrea, Makassar, 90245, Indonesia, unhas.ac.id.ORCID https://orcid.org/0009-0004-4477-9818
Nadila Pratiwi LatadaUnhas Fly Research Group, Faculty of Pharmacy, Hasanuddin University, Tamalanrea, Makassar, 90245, Indonesia, unhas.ac.id.ORCID https://orcid.org/0009-0004-2209-0841
Mukarram MudjahidUnhas Fly Research Group, Faculty of Pharmacy, Hasanuddin University, Tamalanrea, Makassar, 90245, Indonesia, unhas.ac.id.ORCID https://orcid.org/0009-0009-5361-4712
Firzan NainuUnhas Fly Research Group, Faculty of Pharmacy, Hasanuddin University, Tamalanrea, Makassar, 90245, Indonesia, unhas.ac.id.ORCID https://orcid.org/0000-0003-0989-4023

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background & Objective: Diabetes mellitus is a global health issue caused by chronic hyperglycemia. Although various therapeutic options are available, each carries potential side effects, prompting growing interest in exploring natural compounds as alternative treatments. Quercetin, a flavonoid known for its antioxidant and anti-inflammatory properties, is suspected to play a role in glucose regulation, although its molecular mechanisms remain incompletely understood. This study aimed to analyze the Methods: Phenotypic evaluation included measurements of body morphology, locomotor activity, survival rate, and hemolymph glucose levels. Molecular analyses were conducted using reverse transcription quantitative PCR (RT-qPCR), while molecular docking studies were performed to assess quercetin's interaction with the enzyme dipeptidyl peptidase-4 (DPP4). Results: Quercetin significantly reduced hemolymph glucose levels in both larvae ( Conclusion: This study provides both phenotypic and molecular evidence that quercetin exerts hypoglycemic effects in

Indexed as

diabetes mellitusDPP4 inhibitionDrosophila melanogastermolecular dockingquercetin

Identifiers

PMID41777721
PMCPMC12951000

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.