ArticleRegenerative biomaterials2026
Magnetic chitosan nanoparticle-exosome hydrogel enhances bladder function in diabetic bladder dysfunction via activating the FAK-p38 MAPK-GATA4 axis in adipose-derived mesenchymal stromal cells.
Article in Regenerative biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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Who cites it
3 citing papers in PubMed.
- Mitochondrial structural and functional aberrations in diabetic bladder dysfunction: underlying mechanisms and therapeutic landscapes.Acta diabetologica · 2026Review
- Nanorobots and Exosomes: Driving the New Frontier for Bladder Tumors through Non-Coding RNAs.Oncology research · 2026Review
- From physical impact to biological information flow: shock wave regulation of extracellular vesicles mediated tissue repair.Frontiers in cell and developmental biology · 2026Review
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Authors and funding
7 authors.
Funding
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Abstract
Previous attempts to combine adipose-derived mesenchymal stromal cells (ADSCs) with defocused low-energy shock wave (DLSW) have shown effectiveness in treating diabetic bladder dysfunction (DBD). However, the specific mechanisms underlying their therapeutic effects and strategies to enhance the colonization of ADSCs at the disease site remain challenging. Hereby, our investigation revealed that DLSW activated the FAK-p38 MAPK-GATA4 axis in ADSCs, resulting in enhanced secretion of vascular endothelial growth factor (VEGF) and nerve growth factor (NGF). Moreover, tube formation assay and major pelvic ganglia culture showed that the effects of VEGF and NGF on angiogenesis and nerve fiber growth were hindered by adding GATA4 inhibitors. We developed a thermosensitive hydrogel using chitosan nanoparticles (CSNP) incorporated with β-glycerophosphate and Fe
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