ArticlePractical laboratory medicine2026
Comparative evaluation of free light chain assays in AL amyloidosis: Performance of Sebia versus Freelite and N-Latex.
Article in Practical laboratory medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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Abstract
•Analytical performance of the Sebia free light chain ELISA was evaluated in systemic AL amyloidosis and compared with Freelite and N-Latex assays.•Sebia reported lower involved and difference FLC concentrations than comparator assays, particularly in λ-type disease.•Sebia showed reduced detection rates for abnormal κ/λ ratios compared with N-Latex and Freelite, most pronounced in λ-type disease.•Combining Sebia with serum and urine immunofixation improved detection of amyloidogenic clones.•These findings demonstrate that FLC assays are not interchangeable and require assay-specific interpretation.
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