Evidence map›Paper›PMID 41777681›Full record

ArticleClinical kidney journal2026

Ethanol lock therapy for salvage of infected tunnelled haemodialysis catheters: a randomised controlled trial.

Hari Prasad M K, Lalit K Pursnani, Himansu Sekhar Mahapatra, Muthukumar Balkrishnan, Renju Binoy, Vipin Dev, Varuna Yadav, Disha Arora

Abstract read
In one paragraph

Article in Clinical kidney journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Hari Prasad M KDepartment of Nephrology, Atal Bihari Vajpayee Institute of Medical Sciences & Dr Ram Manohar Lohia Hospital, New Delhi, India.ORCID https://orcid.org/0000-0002-9827-3239
Lalit K PursnaniDepartment of Nephrology, Atal Bihari Vajpayee Institute of Medical Sciences & Dr Ram Manohar Lohia Hospital, New Delhi, India.
Himansu Sekhar MahapatraDepartment of Nephrology, Atal Bihari Vajpayee Institute of Medical Sciences & Dr Ram Manohar Lohia Hospital, New Delhi, India.ORCID https://orcid.org/0000-0002-2345-5230
Muthukumar BalkrishnanDepartment of Nephrology, Atal Bihari Vajpayee Institute of Medical Sciences & Dr Ram Manohar Lohia Hospital, New Delhi, India.
Renju BinoyDepartment of Nephrology, Atal Bihari Vajpayee Institute of Medical Sciences & Dr Ram Manohar Lohia Hospital, New Delhi, India.
Vipin DevDepartment of Nephrology, Atal Bihari Vajpayee Institute of Medical Sciences & Dr Ram Manohar Lohia Hospital, New Delhi, India.
Varuna YadavDepartment of Nephrology, Atal Bihari Vajpayee Institute of Medical Sciences & Dr Ram Manohar Lohia Hospital, New Delhi, India.
Disha AroraDepartment of Nephrology, Atal Bihari Vajpayee Institute of Medical Sciences & Dr Ram Manohar Lohia Hospital, New Delhi, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Tunnelled catheter-related bloodstream infections (CRBSIs) in haemodialysis (HD) are challenging to manage due to biofilm formation. Ethanol lock therapy (ELT) has demonstrated potential as an adjunct to antibiotics for catheter salvage, but robust evidence is limited. Methods: We conducted a single-centre, open-label, randomised controlled trial of adult HD patients with suspected or confirmed CRBSI. Patients received either 70% ELT plus intravenous antibiotics or intravenous antibiotics alone. Primary outcome was catheter salvage at day 7. Secondary outcomes included recurrence at day 60, catheter survival and adverse events. Results: Eighty-four patients were randomised (42 per arm). Coagulase-negative Conclusion: Adjunctive ELT improved early catheter salvage and reduced recurrence without significant adverse effects. These findings support its use as part of salvage protocols in tunnelled catheter infections.

Indexed as

catheter-related infectionethanol locktunnelled catheter

Identifiers

PMID41777681
PMCPMC12950961

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