Evidence map›Paper›PMID 41777675›Full record

ArticleFrontiers in aging neuroscience2026

Putative sympathetic-predominant subtype in body-first Parkinson's disease is associated with accelerated cognitive decline.

Xining Liu, Zhiheng Xu, Xiuyuan Li, Chenqin Xu, Shiyu Li, Tianyu Hu, Chen Chen, Xiaoniu Liang, Yilin Tang, Jian Wang

Abstract read
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In one paragraph

Article in Frontiers in aging neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Xining Liu *State Key Laboratory of Brain Function and Disorders, Department of Neurology and National Research Center for Aging and Medicine & National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, China.
Zhiheng Xu *State Key Laboratory of Brain Function and Disorders, Department of Neurology and National Research Center for Aging and Medicine & National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, China.
Xiuyuan Li *State Key Laboratory of Brain Function and Disorders, Department of Neurology and National Research Center for Aging and Medicine & National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, China.
Chenqin XuState Key Laboratory of Brain Function and Disorders, Department of Neurology and National Research Center for Aging and Medicine & National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, China.
Shiyu LiState Key Laboratory of Brain Function and Disorders, Department of Neurology and National Research Center for Aging and Medicine & National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, China.
Tianyu HuState Key Laboratory of Brain Function and Disorders, Department of Neurology and National Research Center for Aging and Medicine & National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, China.
Chen ChenState Key Laboratory of Brain Function and Disorders, Department of Neurology and National Research Center for Aging and Medicine & National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, China.
Xiaoniu LiangState Key Laboratory of Brain Function and Disorders, Department of Neurology and National Research Center for Aging and Medicine & National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, China.
Yilin TangState Key Laboratory of Brain Function and Disorders, Department of Neurology and National Research Center for Aging and Medicine & National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, China.
Jian WangState Key Laboratory of Brain Function and Disorders, Department of Neurology and National Research Center for Aging and Medicine & National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Parkinson's disease (PD) can be classified into brain-first and body-first subtypes based on the initial site of α-synuclein pathology. Postmortem studies further suggest that body-first PD may be divided into two phenotypes: sympathetic-predominant subtype (SPS) and parasympathetic-predominant subtype (PPS). However, studies on longitudinal clinical characteristics of the two putative body-first subtypes are limited. Objectives: We aim to investigate the clinical features of these subtypes. Methods: In a cohort of 73 body-first PD patients, we identified 14 patients with orthostatic hypotension (OH) without constipation (putative SPS) and 40 with constipation without OH (putative PPS). Linear mixed models were used to assess disease progression. Results: Over follow-up, SPS patients exhibited a significantly faster decline in MMSE scores compared with PPS patients ( Conclusion: These findings indicated that sympathetic-predominant body-first PD may be associated with a more rapid trajectory of cognitive decline, although the observed effect was modest and warrants cautious interpretation.

Indexed as

body-first subtypecognitive declinedisease progressionParkinson’ s diseasesympathetic nervous system

Identifiers

PMID41777675
PMCPMC12950674

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