Evidence map›Paper›PMID 41777602›Full record

ReviewFrontiers in bioengineering and biotechnology2026

Penetration depth of cold atmospheric plasma into biological tissue: a review.

Dong Jiang, Jiashuo Zhang, Zhixin Liu, Yilin Yu, Li Xiao, Mi Ai, Ming Luo, Ollie Yiru Yu, Yingguang Cao, Ke Song

Abstract readReview
In one paragraph

Review in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Dong JiangDepartment of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Jiashuo ZhangDepartment of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Zhixin LiuDepartment of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yilin YuDepartment of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Li XiaoDepartment of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Mi AiDepartment of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Ming LuoDepartment of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Ollie Yiru YuFaculty of Dentistry, The University of Hongkong, Hong Kong SAR, China.
Yingguang CaoDepartment of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Ke SongDepartment of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cold atmospheric plasma (CAP) is a non-thermal plasma generated near room temperature that has broad medical applications in the medical field, including antitumor, antimicrobial, and anti-inflammatory effects, promotion of tissue regeneration, and enhancement of transdermal and mucosal drug delivery. However, there is currently a lack of standardization regarding the indications for CAP and its application parameters, resulting in varying degrees of histological penetration depths reported in different studies. Therefore, to further promote the safe and effective clinical application of CAP, the histological levels at which CAP can be applied must be clearly defined. Here, we review the depth of tissue penetration achieved by CAP under various conditions and analyze the key factors influencing penetration depth, using this knowledge to propose how these factors should be adjusted for different application requirements to achieve safer and more precise therapies.

Indexed as

biological tissuecold atmospheric plasmahistological layerspenetration depthreactive oxygen and nitrogen speciestissue model

Identifiers

PMID41777602
PMCPMC12950767

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.