Evidence map›Paper›PMID 41777595›Full record

ReviewMolecular imaging

Advancements in Imaging Technologies and AI Integration for Neurodegenerative Disease Management: A Narrative Review.

Jinshan Xu, Caiyun Gao, Junhua Zhang, Jialei Lu, Yingyu Xuan, Shiyun Wang, Chaozhi Bu

Abstract readReview
In one paragraph

Review in Molecular imaging. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jinshan XuDepartment of Radiology, The Affiliated People's Hospital of Ningbo University, Ningbo, Zhejiang, China.ORCID 0009-0008-6863-3476
Caiyun GaoMarket Supervision and Law Enforcement Guarantee Service Center of Xihu District, Hangzhou, Zhejiang, China.
Junhua ZhangDepartment of Radiology, The Affiliated People's Hospital of Ningbo University, Ningbo, Zhejiang, China.
Jialei LuSchool of Pharmaceutical Sciences, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Yingyu XuanSchool of Pharmaceutical Sciences, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Shiyun WangSchool of Laboratory Medicine and Bioengineering, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Chaozhi BuWuxi Maternity and Child Health Care Hospital, Affiliated Women's Hospital of Jiangnan University, Wuxi, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Neurodegenerative diseases, characterized by progressive neuronal degeneration, are increasingly prevalent due to global aging trends and impose a significant burden on patients. No cure currently exists, with oxidative stress and inflammation serving as key drivers of disease progression. Advances in imaging technologies and artificial intelligence (AI) offer new opportunities for early diagnosis, monitoring, and treatment evaluation. This review aims to summarize the role of advanced neuroimaging modalities and AI integration in improving the diagnosis, monitoring, and management of neurodegenerative diseases, while highlighting current challenges and future directions. Material and Methods: A narrative review was conducted based on published literature on neuroimaging techniques in neurodegenerative diseases. Key modalities included structural and functional magnetic resonance imaging (MRI, fMRI), diffusion tensor imaging (DTI), positron emission tomography (PET), and single-photon emission computed tomography (SPECT). The integration of AI in image analysis was evaluated for its impact on diagnostic accuracy and workflow efficiency. Sources were selected from peer-reviewed journals focusing on clinical applications, technical advancements, and multimodal imaging strategies. Results Structural MRI, fMRI, and DTI provide detailed insights into brain atrophy and microstructural integrity, while PET and SPECT enable molecular-level assessment of metabolism and pathology. AI-enhanced analysis reduces interpretation variability and improves diagnostic precision. Despite these advances, high costs, limited accessibility, and inter-expert subjectivity remain major barriers. Emerging multimodal approaches and AI-driven tools show promise in enabling earlier detection and personalized treatment monitoring. Conclusion: The integration of advanced imaging and AI holds transformative potential for neurodegenerative disease management. Future efforts should prioritize cost reduction, improved accessibility, and seamless multimodal data fusion to translate these technologies into routine clinical practice.

Indexed as

Artificial IntelligenceNeurodegenerative DiseasesNeuroimagingHumansIntelligent SystemsMagnetic Resonance Imagingartificial intelligencediagnosisimaging technologiesneurodegenerative diseases

Identifiers

PMID41777595
PMCPMC12950948

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.