Evidence map›Paper›PMID 41777554›Full record

ArticleRSC medicinal chemistry2026

Harnessing oligonucleotide architecture for potent multivalent inhibition of human carbonic anhydrases.

Eslam M Abbass, Federico Ladu, Justine Mansot, Mathieu Noël, Alessio Nocentini, Mario Sechi, Claudiu T Supuran, Michael Smietana, Jean-Yves Winum

Abstract read
In one paragraph

Article in RSC medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Eslam M AbbassIBMM, University of Montpellier, CNRS, ENSCM Montpellier France michael.smietana@umontpellier.fr jean-yves.winum@umontpellier.fr.ORCID https://orcid.org/0000-0002-3245-1653
Federico LaduIBMM, University of Montpellier, CNRS, ENSCM Montpellier France michael.smietana@umontpellier.fr jean-yves.winum@umontpellier.fr.ORCID https://orcid.org/0000-0003-1080-6967
Justine MansotIBMM, University of Montpellier, CNRS, ENSCM Montpellier France michael.smietana@umontpellier.fr jean-yves.winum@umontpellier.fr.
Mathieu NoëlIBMM, University of Montpellier, CNRS, ENSCM Montpellier France michael.smietana@umontpellier.fr jean-yves.winum@umontpellier.fr.ORCID https://orcid.org/0009-0002-3804-0705
Alessio NocentiniNeurofarba Department, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence Via Ugo Schiff 6, Sesto Fiorentino Florence 50019 Italy.ORCID https://orcid.org/0000-0003-3342-702X
Mario SechiDepartment of Medicine, Surgery and Pharmacy, University of Sassari 07100 Sassari Italy.ORCID https://orcid.org/0000-0003-2983-6090
Claudiu T SupuranNeurofarba Department, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence Via Ugo Schiff 6, Sesto Fiorentino Florence 50019 Italy.ORCID https://orcid.org/0000-0003-4262-0323
Michael SmietanaIBMM, University of Montpellier, CNRS, ENSCM Montpellier France michael.smietana@umontpellier.fr jean-yves.winum@umontpellier.fr.ORCID https://orcid.org/0000-0001-8132-7221
Jean-Yves WinumIBMM, University of Montpellier, CNRS, ENSCM Montpellier France michael.smietana@umontpellier.fr jean-yves.winum@umontpellier.fr.ORCID https://orcid.org/0000-0003-3197-3414

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study presents the design and synthesis of a novel class of carbonic anhydrase inhibitors (CAIs) using oligonucleotides as an original multivalent platform. Single-stranded oligonucleotides bearing one to four terminal alkyne moieties were prepared by solid-phase synthesis using the commercially available 2'-

Identifiers

PMID41777554
PMCPMC12951626

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.