Evidence map›Paper›PMID 41777506›Full record

ArticleNoro psikiyatri arsivi2026

Posterior Atrophy is a Neuroimaging Marker of Mild Cognitive Impairment in Parkinson's Disease.

Ulaş Ay, Zerrin Yıldırım, Ani Kicik, Emel Erdogdu, Başar Bilgiç, Hasmet Hanagasi, Esin Ozturk-Isık, Tamer Demiralp, Hakan Gurvit

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Article in Noro psikiyatri arsivi, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Ulaş AyIstanbul University, Hulusi Behçet Life Sciences Research Center, Neuroimaging Unit, Istanbul, Türkiye.
Zerrin YıldırımIstanbul University, Aziz Sancar Institute of Experimental Medicine, Department of Neuroscience, Istanbul, Türkiye.
Ani KicikDemiroglu Bilim University, Faculty of Medicine, Department of Physiology, Istanbul, Türkiye.
Emel ErdogduIsik University, Faculty of Arts and Sciences, Department of Psychology, Istanbul, Türkiye.
Başar BilgiçIstanbul University, Istanbul Faculty of Medicine, Department of Neurology, Behavioral Neurology and Movement Disorders Unit, Istanbul, Türkiye.
Hasmet HanagasiIstanbul University, Istanbul Faculty of Medicine, Department of Neurology, Behavioral Neurology and Movement Disorders Unit, Istanbul, Türkiye.
Esin Ozturk-IsıkBogazici University, Institute of Biomedical Engineering, Istanbul, Türkiye.
Tamer DemiralpIstanbul University, Hulusi Behçet Life Sciences Research Center, Neuroimaging Unit, Istanbul, Türkiye.
Hakan GurvitIstanbul University, Istanbul Faculty of Medicine, Department of Neurology, Behavioral Neurology and Movement Disorders Unit, Istanbul, Türkiye.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Although there are several studies on the neuroanatomical mechanisms underlying Parkinson's disease (PD)-associated cognitive impairment, the clinical usefulness of the findings from these investigations is limited. In this study, we aimed to identify magnetic resonance imaging (MRI) markers that can be practically utilized for diagnosing PD-associated cognitive impairment using a visual rating scale (VRS). Methods: Anatomical MRIs of cognitively normal (PD-CN), and PD with mild cognitive impairment (PD-MCI) patients were visually evaluated for six bilateral cortical regions. Then, hypothesis-driven cortical thickness analysis (CTA) was performed in the regions obtained from VRS. Results: As a consequence of VRS, a significant difference was found between the two groups with regards to right posterior atrophy (PA) scores (pFDR-corr = 0.042, Cohen's d= 1.06). Hypothesis-driven CTA confirmed the result of VRS by revealing cortical thinning at the precuneus and parieto-occipital sulcus junction (Max. T= 6.171, P= 0.0006, MNI Conclusions: Our findings indicate that right PA atrophy may be helpful for clinicians in the diagnosis of PD-associated cognitive impairment.

Indexed as

Cortical thinningParkinson’s diseaseParkinson’s disease with mild cognitive impairmentposterior atrophyvisual rating scale

Identifiers

PMID41777506
PMCPMC12951501

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