Evidence map›Paper›PMID 41777444›Full record

ArticleEmergency medicine international2026

The Associations Between Fibrinogen and Septic Shock in Critically Ill Patients With Sepsis: A Retrospective Cohort Study.

Jianqin Huang, Murong Lu, Yu Zhai, Jiexuan Xu, Pengcheng Duan, Shuting Liu, Xuemei Liu, Hongjing Yu

Abstract read
In one paragraph

Article in Emergency medicine international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jianqin HuangIntensive Care Unit, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China, gzhmc.edu.cn.ORCID https://orcid.org/0009-0002-9457-2511
Murong LuIntensive Care Unit, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China, gzhmc.edu.cn.
Yu ZhaiDepartment of Cardiovascular Medicine, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China, gzhmc.edu.cn.
Jiexuan XuIntensive Care Unit, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China, gzhmc.edu.cn.ORCID https://orcid.org/0009-0002-9775-1267
Pengcheng DuanIntensive Care Unit, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China, gzhmc.edu.cn.ORCID https://orcid.org/0009-0003-7686-987X
Shuting LiuIntensive Care Unit, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China, gzhmc.edu.cn.
Xuemei LiuNursing Administration Department, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China, gzhmc.edu.cn.
Hongjing YuNursing Administration Department, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China, gzhmc.edu.cn.ORCID https://orcid.org/0000-0003-0547-5921

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Fibrinogen has been used as a prognostic indicator for sepsis. However, the associations of fibrinogen and septic shock in septic patients remain unclear. This study aimed to explore the relationship between fibrinogen levels and the occurrence of septic shock in patients with sepsis. Methods: Data were retrospectively analyzed from the Medical Information Mart for Intensive Care IV (MIMIC-IV v3.1) database. The Boruta algorithm and random forest model were used for feature selection to ensure the important variables affecting results. Multivariate logistic regression assessed the association between fibrinogen and septic shock. Subgroup analysis was conducted to evaluate the impact of additional variables on the results. Results: The study included 3302 septic patients. Fibrinogen was significantly associated with septic shock (odds ratio [OR] = 1.46; 95% confidence interval [CI], 1.35-1.56), and the risk of septic shock increased with higher fibrinogen levels (all Conclusion: A linear relationship was found between fibrinogen levels and septic shock. Elevated fibrinogen levels were linked to a higher risk of septic shock in septic patients.

Indexed as

fibrinogenintensive care unitMIMIC databasesepsisseptic shock

Identifiers

PMID41777444
PMCPMC12951003

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.