Evidence map›Paper›PMID 41777298›Full record

ArticleChem & bio engineering2026

Changes in the pH-Activity Profiles of Enzymes upon Immobilization on Polyelectrolyte-Containing Hydrogels.

Nikita M Ivanov, Anastasia T Tsitsimeli, Wilhelm T S Huck

Abstract read
In one paragraph

Article in Chem & bio engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Nikita M IvanovInstitute for Molecules and Materials, Radboud University, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands.ORCID https://orcid.org/0000-0002-6377-3241
Anastasia T TsitsimeliInstitute for Molecules and Materials, Radboud University, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands.
Wilhelm T S HuckInstitute for Molecules and Materials, Radboud University, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands.ORCID https://orcid.org/0000-0003-4222-5411

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Understanding changes in the physicochemical properties of enzymes upon immobilization is the key to optimizing their activities. Immobilization on or modification with polyelectrolytes will induce shifts in the pH-activity profiles of enzymes, but a systematic study comparing various enzymes and polyelectrolyte supports is lacking. Here, we report the pH-activity profiles of eight enzymes immobilized via covalent bonds within six different polyacrylamide-

Indexed as

activity enhancementenzyme immobilizationenzyme-polymer conjugatepH-activity profilepolyelectrolyte

Identifiers

PMID41777298
PMCPMC12951235

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.